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This volume connects current ideas and concepts about sleep functions and circadian rhythms with the search for novel target-selective sleep-wake therapeutics. To do so, it provides a timely, state-of-the-art overview of sleep-wake mechanisms in health and disease, ongoing developments in drug discovery, and their prospects for the clinical treatment of sleep-disordered patients. It particularly focuses on the concept that sleep and wakefulness mutually affect each other, and the future therapeutic interventions with either sleep- or wake-promoting agents that are expected to not only improve the quality of sleep but also the waking behavior, cognition, mood and other sleep-associated physiological functions. The chapter 'Sleep Physiology, Circadian Rhythms, Waking Performance and the Development of Sleep-Wake Therapeutics' available open access under a CC BY 4.0 license at link.springer.com
Burger’s Medicinal Chemistry, Drug Discovery and Development Explore the freshly updated flagship reference for medicinal chemists and pharmaceutical professionals The newly revised eighth edition of the eight-volume Burger’s Medicinal Chemistry, Drug Discovery and Development is the latest installment in this celebrated series covering the entirety of the drug development and discovery process. With the addition of expert editors in each subject area, this eight-volume set adds 35 chapters to the extensive existing chapters. New additions include analyses of opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic co...
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These Treatises of the Odu of Ifá in volumes, are very complete, since In addition to treating the Afro-Cuban Odu de Ifá, they also contain Traditional African Ifá treatises. Both gather thousands of Pataki or Histories, thousands of Eboses and works, which will make it easier for you to deepen your study and solve any situation that arises in the religious field of consulting the Ifa oracle. The Synthesis of the Treaties of the Odu of Ifá already published by me previously, is nothing more than as its name indicates, a synthesis of these treaties, whose objective was always to support to the Babalawo as a handy pocket reminder, based on the fact that it has been studied and deepened before in the study of these volumes which will lead you to have the most complete knowledge about Ifá. For these reasons, it is highly recommended to have this valuable information in your library. We have grouped only two Odu per book, to make it as cheap as possible and facilitate its acquisition.
The book reviews clinical trial methodology as it pertains to drug development in psychiatry. The reader will understand the process of drug development in psychiatry from discovery through marketing with the help of clinically relevant examples. The reader will appreciate the history of drug development in psychiatry dating back to the era of serendipitous discovery and culminating in an era of new and highly focused targets. Readers will understand how drug development in psychiatry has changed and adapted with the discovery of novel mechanism of action drugs. Novel drugs and disease targets have changed the way developers and regulatory agencies think about clinical trial methodology. The...
Master the basics of sleep medicine with this easy to read, award-winning text! Fundamentals of Sleep Medicine, 2nd Edition, by Drs. Richard B. Berry, Mary H. Wagner, and Scott M. Ryals, is an ideal resource for sleep medicine fellows and trainees, sleep technicians, and sleep medicine practitioners as a concise, clinically focused alternative to larger references. Beginning with core content, it then proceeds to information useful for everyday practice—all written in a clear, direct style designed for quick and easy access. - Features video content that demonstrates common sleep disorders. - Includes more than 350 updated multiple-choice questions and answers for self-assessment and board...
This book provides insights of World Conference on Smart Trends in Systems, Security and Sustainability (WS4 2022) which is divided into different sections such as Smart IT Infrastructure for Sustainable Society; Smart Management Prospective for Sustainable Society; Smart Secure Systems for Next Generation Technologies; Smart Trends for Computational Graphics and Image Modeling; and Smart Trends for Biomedical and Health Informatics. The proceedings is presented in two volumes. The book is helpful for active researchers and practitioners in the field.
This new edition describes the state of the art regarding molecular catalysts such as MN4 metal complexes, like porphyrins and phthalocyanines. This volume focuses on the particular case of the electrocatalysis of the reduction of O2 for practical applications in fuel cells and air batteries. Indeed, active and stable materials have been developed in the last 5 years where MN4 catalytic systems can be obtained by the pyrolysis of starting materials that do not necessarily involve MN4 complexes. These latter systems constitute a new class of stable and highly active non-precious metal catalysts for ORR that can replace expensive Platinum containing electrodes. The book also offers future projections and points out new fields of research and development of these non-precious metal catalysts.