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Intermediate Filaments focuses on desmin and other intermediate filaments in disease and health. This new volume will serve as a resource for graduate students and researchers in the field.
PALEONTOLOGICAL DATA ANALYSIS An up-to-date edition of the indispensable guide to analysing paleontological data Paleontology has developed in recent decades into an increasingly data-driven discipline, which brings to bear a huge variety of statistical tools. Applying statistical methods to paleontological data requires a discipline-specific understanding of which methods and parameters are the most appropriate ones, and how to account for statistical bias inherent in the fossil record. By guiding the reader to these and other fundamental questions in the statistical analysis of fossilized specimens, Paleontological Data Analysis has become the standard text for anyone with an interest in q...
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Uses Computational Tools to Simulate Endocrine Disruption PhenomenaEndocrine Disruption Modeling provides a practical overview of the current approaches for modeling endocrine activity and the related potential adverse effects they may induce on environmental and human health. Based on the extensive research of an international panel of contributor
Epigenetics is defined as the study of modifications of the genome, heritable during cell division that does not involve changes in DNA sequences. Up to date, epigenetic modifications involve at least three general mechanisms regulating gene expression: histone modifications, DNA methylation, and non-coding RNAs (ncRNAs). For the past two decades, an explosion in our interest and understanding of epigenetic mechanisms has been seen. This mainly based on the influence that epigenetic alterations have on an amazing number of biological processes, such as gene expression, imprinting, programmed DNA rearrangements, germ line silencing, developmentally cued stem cell division, and overall chromos...
This volume provides a picture of the state of the art and of the perspectives opened by new powerful approaches to the study of the structure and function of Circumventricular Organs (CVOs). Studies on the CVOs reflected in this book comprise many aspects, from cellular elements to the whole organism: the accessibility of these organs for chemical signals, signal (ligand)-receptor interactions, the transfer of information to distinct brain regions, the effects induced in these brain regions and the influence on the regulation of body functions including autonomic and behavioral alterations. Some of these aspects strongly depend upon the microenvironment of the cells involved in this cascade of events. Therefore, the brain fluid environment in its broadest sense is a central focus. This excellent work is therefore an up-to-date report on interdisciplinary approaches and concepts, offering new insights into the complex phenomena of brain function, and shows directions in which to proceed."