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This is Big
'A life-changing book' Viv Groskop Marisa Meltzer was put on her first diet aged five: it was the beginning of a fraught relationship with food. Jean Nidetch was a housewife from Queens who defiantly lost 70 pounds after she was mistaken for being pregnant. Taking everything she learned from this experience, in 1963 she founded Weight Watchers, a company that has shaped decades of diet culture. When Marisa reads Jean's obituary, she feels a moment of intense connection. Curious about the woman and her legacy, she signs up for a year of Weight Watchers; counting points, weighing in and listening to her fellow members struggle with their bodies. This is Big is a biography of an idiosyncratic entrepreneur whose impact is still felt strongly today. It is a history of dieting and body politics for anyone who has agonised over their weight or defiantly tried not to do so. And it is Marisa's funny and thoughtful journey towards a different way to live in the world. 'This is the anti-diet book I've been waiting for' Daisy Buchanan
A New Day
This big-hearted story of kindness—reminiscent of The Day the Crayons Quit—is written by the bestselling author of Ordinary People Change the World and illustrated by the Caldecott Medal-winning creator of Beekle. Sunday quit, just like that. She said she was tired of being a day. And so the other days of the week had no choice but to advertise: "WANTED: A NEW DAY. Must be relaxing, tranquil, and replenishing. Serious inquires only." Soon lots of hopefuls arrived with their suggestions, such as Funday, Bunday, Acrobaturday, SuperheroDay, and even MonstersWhoResembleJellyfishDay! Things quickly got out of hand . . . until one more candidate showed up: a little girl with a thank-you gift for Sunday. The girl suggested simply a nice day--a day to be kind. And her gratitude made a calendar's worth of difference to Sunday, who decided she didn't need to quit after all. When we appreciate each other a little bit more, all the days of the week can be brand-new days where everything is possible.
Hormones, Brain and Behavior
Hormones, Brain and Behavior, Third Edition offers a state-of-the-art overview of hormonally-mediated behaviors, including an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. Entries have been carefully designed to provide a valuable source of information for students and researchers in neuroendocrinology and those working in related areas, such as biology, psychology, psychiatry, and neurology. This third edition has been substantially restructured to include both foundational information and recent developments in the field. Continuing the emphasis on interdisciplinary research and practical applications, the book includes articles a...
Mood Disorders
Written by an outstanding team of internationally recognised experts, this practical textbook is based on the European Certificate in Anxiety and Mood Disorders. It provides a thorough overview of diagnosis and treatment of mood disorders and analyses the most recent developments and scientific evidence. Covers the most important clinical topics in the field, including symptomatology, natural course and diagnosis Treatment strategies are reviewed in the light of all available empirical evidence Outstanding list of international contributors
Current Antipsychotics
Six decades after the serendipitous discovery of chlorpromazine as an antipsychotic and four decades after the launch of clozapine, the first atypical or second generation antipsychotic, psychopharmacology has arrived at an important crossroad. It is clear that pharmacological research and pharmaceutical development must now focus on complementary or even alternative mechanisms of action to address unmet medical needs, i.e. poorly treated domains of schizophrenia, improved acceptance by patients, better adherence to medication, safety in psychoses in demented patients, and avoiding cardiac and metabolic adverse effects. The first completely novel mechanisms evolving from our insights into th...
Bioinformatics
"In this book, Andy Baxevanis and Francis Ouellette . . . haveundertaken the difficult task of organizing the knowledge in thisfield in a logical progression and presenting it in a digestibleform. And they have done an excellent job. This fine text will makea major impact on biological research and, in turn, on progress inbiomedicine. We are all in their debt." —Eric Lander from the Foreword Reviews from the First Edition "...provides a broad overview of the basic tools for sequenceanalysis ... For biologists approaching this subject for the firsttime, it will be a very useful handbook to keep on the shelf afterthe first reading, close to the computer." —Nature Structural Biology "...sho...
First Peoples in a New World
A study of Ice Age Americans, highlighting genetic, archaeological and geological evidence that has revolutionized our understanding of their origins, antiquity, and adaptations.
Computational and Statistical Approaches to Genomics
Computational and Statistical Genomics aims to help researchers deal with current genomic challenges. Topics covered include: overviews of the role of supercomputers in genomics research, the existing challenges and directions in image processing for microarray technology, and web-based tools for microarray data analysis; approaches to the global modeling and analysis of gene regulatory networks and transcriptional control, using methods, theories, and tools from signal processing, machine learning, information theory, and control theory; state-of-the-art tools in Boolean function theory, time-frequency analysis, pattern recognition, and unsupervised learning, applied to cancer classification, identification of biologically active sites, and visualization of gene expression data; crucial issues associated with statistical analysis of microarray data, statistics and stochastic analysis of gene expression levels in a single cell, statistically sound design of microarray studies and experiments; and biological and medical implications of genomics research.
Cytokines, Stress, and Depression
Cytokines had been characterized in the early eighties as communication mole cules between immune cells, and between immunocytes and other peripheral cells, such as fibroblasts and endothelial cells. They play a key role in the regulation of the immune response and the coordination of the host response to infection. Based on these biological properties, nobody would have predicted that one decade later cytokines would burst upon neurosciences and permeate into several avenues of current research. In neurology, the connection between cytokines and inflammation, and the demonstration of a pivotal role of some of these molecules in cell death by apoptosis, prompted the investigation of their in...
