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Advances in DNA Sequence-specific Agents
In this volume the entire focus is devoted to the macromolecule target specificity of DNA interactive developmental therapeutic agents of current interest. A brief introduction to DNA interactive anticancer agents is included for readers who may benefit from an overview surrounding the developments that have contributed to our general understanding of this field. The following nine chapters have been carefully chosen so that they describe topics which are at the forefront of development in DNA-targeted cancer chemotherapy. Issues that have been addressed include the mechanisms of selective DNA topoisomerase I and II poisoning by antitumor agents (Chapters 1 and 2), sequence-specific recognit...
Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set
Burger’s Medicinal Chemistry, Drug Discovery and Development Explore the freshly updated flagship reference for medicinal chemists and pharmaceutical professionals The newly revised eighth edition of the eight-volume Burger’s Medicinal Chemistry, Drug Discovery and Development is the latest installment in this celebrated series covering the entirety of the drug development and discovery process. With the addition of expert editors in each subject area, this eight-volume set adds 35 chapters to the extensive existing chapters. New additions include analyses of opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic co...
Terrestrial Heat Flow in Europe
The outflow of heat from the earth's interior, the terrestrial heat flow, and the temperature field at depth are determined by deep-seated tectonic processes. The knowledge of the re gional heat flow pattern is thus very important in geophysics and provides a useful tool for studying crustal and litho spheric structure and understanding the nature of their evo lution. In order to use the results of heat flow measurements for regional studies and/or to correlate the observed surface geothermal activity with other geophysical or geological fea tures, a map showing the surface distribution of heat flow is necessary. Since 1963, when the first comprehensive listing of all available heat flow dat...
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The Plasma Proteins
The Plasma Proteins: Structure, Function, and Genetic Control, Second Edition, Volume I is a systematic account of the structure, function, and genetic control of plasma proteins. Clinical relevance is introduced in terms of principles, with emphasis on human proteins. Animal proteins are also used as examples in some cases. Comprised of nine chapters, this volume begins with a historical background on plasma proteins, along with their nomenclature, characterization, and genetic markers. The primary structure and three-dimensional conformation of plasma proteins are also considered. The discussion then turns to the chemical, physical, and biological properties of various plasma proteins such...
The Adria Microplate: GPS Geodesy, Tectonics and Hazards
Tectonic motion of the Adria microplate exerts a first-order control on the tectonics, geology, seismology, resource distribution, and the geological hazards across a broad zone of south-central Europe and the north-central Mediterranean. Since its first application to geodynamical problems, GPS geodesy has gradually revealed the nature of motion and deformation for most active areas of deformation across the Earth. One of the last remaining regional-scale problems on the planet is the motion and associated deformation in the peri-Adriatic region. Selected local-scale studies have examined aspects of this motion, but to date no truly regional analysis or regional team has systematically atta...
