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Biophysical and Biochemical Mechanisms of Organism Development in Norm and Pathology
This book advances the knowledge of the mechanism development of a lived organism during its lifetime through the normal stationary state and quasi-stationary pathologic state from the viewpoints of biochemistry, biophysics, and thermodynamics. It explores the possibility of estimating experimental results from the three points of view, giving a broad perspective on the interaction between an organism and its environment. The book also describes the biophysical and biochemical mechanisms’ maintenance stability of internal energy according to the First and Second Law of Thermodynamics.
Oxidoreductase
Oxidoreductase enzymes are a group of enzymes that catalyzes the transfer of electrons from one molecule, the reductant, also called the electron donor, to another, the oxidant, also called the electron acceptor. Oxidoreductase enzymes utilize NADP+ or NAD+ as cofactors. Oxidoreductase enzymes include the following: oxidase, dehydrogenase, peroxidase, hydroxylase, oxygenase, and reductase. Most oxidoreductase enzymes are dehydrogenases. However, reductases are also common. The accepted nomenclature for dehydrogenases is “donor dehydrogenase”, where the donor is the oxidized substrate. Metabolic abnormalities disorders resulting from a deficiency (quantitative and qualitative) or from ove...
Reactive Oxygen Species
Reactive Oxygen Species (ROS) are molecules generated naturally during cellular metabolic processes. They act as signaling agents that oversee specific biochemical pathways, playing a vital role in cell function and survival. However, an imbalance in ROS signaling or excessive ROS production can have harmful effects on the pathophysiology of diseases. ROS are crucial to cell signaling and are involved in various physiological processes. They modulate gene expression, regulate cell cycle progression, and influence immune responses. Although ROS are essential for normal cellular functions, an overabundance of these molecules can lead to oxidative stress, causing DNA damage, lipid peroxidation,...
Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition
Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition explores thiamine and how its deficiency affects the functions of the brainstem and autonomic nervous system by way of metabolic changes at the level of the mitochondria. Thiamine deficiency derails mitochondrial oxidative metabolism and gives rise to the classic disease of beriberi that, in its early stages, can be considered the prototype for a set of disorders that we now recognize as dysautonomia. This book represents the life's work of the senior author, Dr. Derrick Lonsdale, and a recent collaboration with his co-author Dr. Chandler Marrs. - Presents clinical experience and animal research that have answered questions about thiamine chemistry - Demonstrates that the consumption of empty calories can result in clinical effects that lead to misdiagnosis - Addresses the biochemical changes induced by vitamin deficiency, particularly that of thiamine
Sustainable Energy Technologies
This book examines the key aspects that will define future sustainable energy systems: energy supply, energy storage, security and limited environmental impacts. It clearly explains the need for an integrated engineering approach to sustainable energies, based on mathematical, biogeophysical, and engineering arguments. Resilient and efficient alternatives are compared to non-sustainable options. This book results from the collaboration of 50 international contributors.
Applied human rights
What do human rights look like when we present them as action-based, bottom-up concepts, and not exclusively as legal items? After all, when we narrow down human rights to a legal concept only, we do not do justice to its meaning. In many professions and branches the idea of human rights is used in jargon, as guiding principles and as a source of inspiration. Human rights make a difference, albeit not necessarily as an enforceable legal concept. This facet of human rights - its practical application beyond lawmakers and lawyers - is deeply underexplored and deserves much more attention. Applied human rights are not per se a matter of lawmaking and enforcement only: it can be part of a missio...
Transforming Multicultural Education Policy and Practice
Join us in celebrating the 25th anniversary of James A. Banks’ Multicultural Education Series, published by Teachers College Press—a dynamic series consisting of more than 70 published books with many more in the pipeline. This commemorative volume features engaging, incisive, and timely selections from the bestselling and most influential books in the series. Together, these selections address how multicultural education should be transformed for a nation and world that are becoming increasingly complex due to virulent racism, pernicious nationalism, mass migrations, interracial mixing, social-class stratification, and a global pandemic. Book Features: Informative and engaging selection...
