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Hypergeometric Orthogonal Polynomials and Their q-Analogues
The present book is about the Askey scheme and the q-Askey scheme, which are graphically displayed right before chapter 9 and chapter 14, respectively. The fa- lies of orthogonal polynomials in these two schemes generalize the classical orth- onal polynomials (Jacobi, Laguerre and Hermite polynomials) and they have pr- erties similar to them. In fact, they have properties so similar that I am inclined (f- lowing Andrews & Askey [34]) to call all families in the (q-)Askey scheme classical orthogonal polynomials, and to call the Jacobi, Laguerre and Hermite polynomials very classical orthogonal polynomials. These very classical orthogonal polynomials are good friends of mine since - most the b...
Thoracic Ultrasound
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All the Things We Never Said
Sixteen-year-old Mehreen is overwhelmed by her anxiety and depression, and she doesn't believe anyone in her life will understand if she tries to talk about it. She's been thinking about suicide for a while when she discovers a website called MementoMori.com. The site matches people with partners and assigns them a date on which to end their lives, together. Mehreen is partnered with Cara and Olivia, strangers dealing with their own struggles. But as the girls get to know one another in preparation for their "date of termination" they find themselves developing a strong bond—even becoming friends. For the first time, they're each able to share their darkest secrets with people who won't judge them. They realize that, with the right support systems, life is worth living after all. So they decide to abandon the suicide pact. Except the website won't let them stop. As their assigned "date of termination" draws nearer and MementoMori continues to manipulate them, the girls will have to rely on one another to survive. If you or a loved one is experiencing suicidal thoughts, call or text 988 to reach the Suicide and Crisis Lifeline for free, confidential 24/7 support.
The Flavonoids
The flavonoids, one of the most numerous and widespread groups of natural constituents, are important to man not only because they contribute to plant colour but also because many members (e.g. coumestrol, phloridzin, rotenone) are physiologically active. Nearly two thousand substances have been described and as a group they are universally distributed among vascular plants. Although the anthocyanins have an undisputed function as plant pigments, the raison d'etre for the more widely distributed colourless flavones and flavonols still remains a mystery. It is perhaps the challenge of discovering these yet undisc10sed functions which has caused the considerable resurgence of interest in flavo...
Cytotoxic Payloads for Antibody–Drug Conjugates
Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (Kadcyla™), brentuximab vedotin (Adcetris™), inotuzumab ozogamicin (Besponsa™), gemtuzumab ozogamicin (Mylotarg™) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages in...
American Environmentalism
Protecting the natural environment and promoting sustainability have become important objectives, but achieving such goals presents myriad challenges for even the most committed environmentalist. American Environmentalism: Philosophy, History, and Public Policy examines whether competing interests can be reconciled while developing consistent, coherent, effective public policy to regulate uses and protection of the natural environment without destroying the national economy. It then reviews a range of possible solutions. The book delves into key normative concepts that undergird American perspectives on nature by providing an overview of philosophical concepts found in the western intellectu...
Arsenic
This book illustrates the chemistry, toxicology, and health effects of arsenic using novel modeling techniques, case studies, experimental data, and future perspectives. • Covers exposure sources, health risks, and mechanisms of one of the most toxic minerals in the world • Helps readers understand potential health effects of arsenic, using population studies, mammalian and invertebrate models, and pharmacokinetic and toxicokinetic models • Discusses outcomes, epidemiology, real-life examples, and modes of action for arsenic-induced diseases, like lung cancer, diabetes, cardiovascular and pulmonary diseases, and immunotoxicity • Acts as a reference for toxicologists, environmental chemists, and risk assessors and includes up-to-date, novel modeling techniques for scientists • Includes future perspectives on special topics, like extrapolation from experimental models to human exposures, biomarkers for phenotypic anchoring, and pathology of chronic exposure
Index Medicus
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