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Both pain and addiction are tremendous public health problems. Practitioners of every stripe say that they learned precious little about pain or addiction in their training and readily admit that instruction on the interface of pain and addiction is nonexistent. The recent problem of prescription drug abuse has only served to highlight the fact that these two worlds need unificationthose who treat pain must be informed about the risks of controlled substances and those who treat addiction need to better and more fully understand their benefits. Nowhere is the pooled knowledge of pain management and addiction medicine brought together to allow for a greater appreciation of the risks of addict...
The papers in this volume were presented at the Third Workshop on Algorithmsand Data Structures (WADS '93), held in Montreal, Canada, August 1993. The volume opens with five invited presentations: "Computing the all-pairs longest chains in the plane" by M.J. Atallah and D.Z. Chen, "Towards a better understanding of pure packet routing" by A. Borodin, "Tolerating faults in meshes and other networks" (abstract) by R. Cole, "A generalization of binary search" by R.M. Karp, and "Groups and algebraic complexity" (abstract) by A.C. Yao. The volume continues with 52 regular presentations selected from 165 submissions, each of which was evaluated by at least three program committee members, many of whom called upon additional reviewers.
Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasis on how the inevitable problems that arise during any project can be surmounted or overcome. The Editors cover a wide range of therapeutic areas and medicinal chemistry strategies, including lead optimization starting from high-throughput screening "hits" as well as rational, structure-based design. The chapters include "follow-ons" and "next generation" compounds that aim to improve upon first-generation agents. This volume surveys the range of challenges commonly faced by medicinal chemistry researchers, including the optimization of metabolism and pharmacokinetics, toxicology, pharmac...
The book provides an introduction to all aspects of the physics of quasicrystals. The chapters, each written by an expert in this field, cover quasiperiodic tilings and the modeling of the atomic structure of quasicrystals. The electronic density of states and the calculation of the electronic structure play a key role in this introduction, as does an extensive discussion of the atomic dynamics. The study of defects in quasicrystals by high resolution electron microscopy and the computer simulations of defects and fracture in decorated tilings are important subjects for the application of these aperiodic crystals.
Historically the field of endocrine research has always been at the forefront of scientific endeavors. The investigators of these important breakthroughs in research have been rewarded by numerous Nobel awards. In the field of diabetes alone, Nobel prizes have been awarded to researchers who discovered insulin, characterized the protein and invented radioimmunoassays using insulin as a paradigm. Not surprisingly, biomedical researchers have always been attracted by the endocrine system and other similar systems of intercellular communication.Over the past two decades, endocrine research has developed rapidly and adapted modern molecular and cellular biology techniques for its specific use. T...
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Covers receipts and expenditures of appropriations and other funds.