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Regulatory T Cells in Inflammation
Regulatory T-cells are essential components of the immune system, and several different subsets of regulatory T-cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T-cell subset. These cells act by suppressing adaptive and possibly innate immune responses thereby maintaining or restoring the balance between immunity and tolerance. The suppressive effects of CD4+CD25+ regulatory T-cells are cell-contact dependent. Recent developments and viewpoints in the field of CD4+CD25+ regulatory T-cells as well as the potential use of regulatory T-cells in immunotherapy of inflammatory diseases are discussed in this volume. By linking data from experimental models with recent findings from the clinic, this book will be of interest to immunologists and other biomedical researchers as well as clinicians interested in the regulation and manipulation of the immune response during inflammatory disease.
Macromolecular Mechanochemistry
This book is an extremely detailed account of all aspects of macromolecular mechanochemistry and will be of great interest to all experts in this area of rapidly advancing mechanochemistry. Mechanochemical transformations are the subject of increasing attention in solid state chemistry, physics and materials science as well as in development of advanced technologies. They have been discussed at a number of symposia on mechanochemistry and mechanical alloying in various countries. The book is divided into the following sections: Polystage feature of mechanochemical process Polymer mechanochemistry deformation Mechanodegradation Influence of some factors on mechanochemical degradation Effect of mechanodegradation on the structure and properties of polymers Polymer fracture Fracture of composite materials
Nuclear Emergencies
This book discusses nuclear events that may become imminent threats to the fabric of our society, and elucidates strategies for preventing these threats or mitigating their adverse effects. It addresses multidisciplinary aspects of various nuclear emergencies, including nuclear accidents, terror attacks involving nuclear materials, illicit trafficking of nuclear materials, and problems related to nuclear forensics and strikes with nuclear weapons/warheads. Very often, nuclear emergencies are only discussed within certain, specific communities. However, this volume brings together experts from various fields to provide a more holistic approach to the problem. Physical, chemical, environmental, social, and medical scientists, together with representatives from the media and authorities, present their views on and strategies for events that cause fear and anxiety among the public – an aspect that can be even more threatening than the direct health effects. The book offers a valuable guide for nuclear scientists, such as radioecologists, health physicists, radioanalytical scientists and nuclear engineers, as well as decision-makers and national/international authorities.
Advances in Food Research
Advances in Food Research
The Molecular Mechanisms of Regulatory T cell Immunosuppression
Ever since Regulatory T cells (T-Regs) were first defined as peripheral CD4+ T cells that express the interleukin-2 (IL-2) receptor alpha chain (IL-2Ra), there have been intensive efforts to determine the molecular mechanisms whereby this minor subset of CD4+ T cells (~ 5-10%) nonspecifically suppresses all potential effector T cells, whether reactive to self or non-self antigens. Multiple possible molecular mechanisms have been implicated, including the scavenging of IL-2 via the expression of high densities of IL-2Rs, the inhibition of antigen presentation via CTLA-4 molecules leading to decreased IL-2 production, the activation of intracellular cAMP thereby suppressing both IL-2 productio...
Activation and Catalytic Reactions of Saturated Hydrocarbons in the Presence of Metal Complexes
hemistry is the science about breaking and forming of bonds between atoms. One of the most important processes for organic chemistry is breaking bonds C–H, as well as C–C in various compounds, and primarily, in hydrocarbons. Among hydrocarbons, saturated hydrocarbons, alkanes (methane, ethane, propane, hexane etc. ), are especially attractive as substrates for chemical transformations. This is because, on the one hand, alkanes are the main constituents of oil and natural gas, and consequently are the principal feedstocks for chemical industry. On the other hand, these substances are known to be the less reactive organic compounds. Saturated hydrocarbons may be called the “noble gases o...
Sendai Virus Vector
Sendai virus (SeV) is not just a mouse pathogen but is evolving into a cutting-edge component of biotechnology. SeV reverse genetics originating from a pure academic need to settle long-held questions in the biology and pathogenicity of nonsegmented negative strand RNA viruses (Mononegavirales) is about to bear the impressive fruit of multipurpose cytoplasmic (non-integrating) RNA vectors. This book brings together in one source the SeV biology revealed by conventional approaches and reverse genetics, the methods to construct the first-generation SeV vector and to generate safer versions, and the applications in medical settings that have left or are about to leave the laboratory bench. The ...
Handbook of Natural Toxins
Volume 4.
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
