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Handbook of Neurochemistry and Molecular Neurobiology
Contents include: 'Biochemistry and molecular biology of neural lipids', 'Advances in lipid analysis/lipidomics', 'Metabolism and enzymology of glycerolipids', 'Lipid metabolism in brain development and aging', 'Cellular and subcellular localization of neural lipids', and much more.
Handbook of Endocrinology, Second Edition, Volume I
Stay on top of the rapid changes sweeping endocrinology today with the latest information on important selected topics in The Handbook of Endocrinology. This extensive two-volume text provides an impressive breadth and depth of coverage difficult to find in other sources. After a broad survey of the functions of major endocrine glands, the book launches into detailed reviews of both established and hot, new research areas. Selected topics include:
The High-Mountain Cryosphere
This book provides a definitive overview of the global drivers of high-mountain cryosphere change and their implications for people across high-mountain regions.
Genes and Resistance to Disease
The advances in human genetics that have ocurred during the past 20 years have revolutionized our knowledge of the role played by inheritance in health and disase. It is clear that our DNA determines not only the emergence of catastrophic single-gene disorders, which affect millions of persons worldwide, but also interacts with environments to predispose individuals to cancer, allergy, hypertension, heart disease, diabetes, psychiatric disorders and even to some infectious diseases. Overall, the study of longevity and the demonstration of genes favouring a long lifespan suggest that such protective systems exist. In recent years, the study of genetic polymorphisms has made clear that some alleles have beneficial effects. These discoveries can substantially improve our understanding of the interactions between genetics and the environment, between pathogenetic mechanisms and new treatments.
MicroRNA Interference Technologies
MicroRNAs (miRNAs), endogenous noncoding regulatory mRNAs of around 22-nucleotides long, have rapidly emerged as one of the key governors of the gene expression regulatory program in cells of varying species, with ever-increasing implications in the control of the fundamental biological processes and in the pathogenesis of adult humans. The exciting findings in this field have inspired us with a premise and a promise that miRNAs will ultimately be taken to the heart for therapy of human disease. While miRNAs have been considered potential therapeutic targets for disease treatment, it remains obscured what strategies we can use to achieve the goal. In the past years, we have witnessed a rapid...
MicroRNAs in Medicine
MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening in the emerging field of microRNAs and their relevance to medicine. Each chapter is a comprehensive review, with descriptions of the latest microRNA research written by international leaders in their field. Opening with an introduction to what microRNAs are and how they function, the book goes on to explore the role of microRNAs in normal physiological functions, infectious diseases, non-infectious diseases, cancer, circulating microRNAs as non-invasive biomarkers, and finally their potential as novel therapeutics. Including background information on the field as well as reviews of the latest research breakthroughs, MicroRNAs in Medicine is a one-stop source of information to satisfy the specialists and non-specialists alike, appealing to students, researchers, and clinicians interested in understanding the potential of microRNAs in medicine and research.
Advances in Debris-flow Science and Practice
Zusammenfassung: This book provides a summary of the state of the art of all facets of debris-flow science and practice and is designed to be a comprehensive technical reference for practitioners and a state-of-the-art research overview for scientists. It is richly illustrated with equations, graphs, photos, and tables. The book allows students, practitioners, and regulators to get a sense of the current state of the art in this science. Currently, there are 2 to 3 papers published every week on some aspects of debris-flow science. This creates a bewildering amount of literature that cannot be captured by a single individual. This book provides a comprehensive overview of all facets to date, including initial hazard assessments, detailed quantitative risk assessments, debris-flow warning systems, debris-flow mitigation structure designs, and failures of mitigation works, as well as new topics such as climate change effects on debris flows
Mountain Landscapes in Transition
This book compiles available knowledge of the response of mountain ecosystems to recent climate and land use change and intends to bridge the gap between science, policy and the community concerned. The chapters present key concepts, major drivers and key processes of mountain response, providing transdisciplinary orientation to mountain studies incorporating experiences of academics, community leaders and policy-makers from developed and less developed countries. The book chapters are arranged in two sections. The first section concerns the response processes of mountain environments to climate change. This section addresses climate change itself (past, current and future changes of tempera...
Principles of Alluvial Fan Morphology
This book offers a comprehensive overview of the alluvial fan phenomena, including all terminology, morphology, sedimentology, controlling factors, processes and the human impact. It combines the knowledge dispersed widely in existing literature with regional case studies, color figures and photographs. The chapters provide a useful basis to understand alluvial fans and a selection of papers attached to each chapter offers additional, more focused reading. This volume is aimed at engineers, planners and especially students in earth sciences.
Inflammation, Oxidative Stress, and Cancer
Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and
