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Beta-Lactams
This book presents an essential overview of beta-lactams and their medicinal value and use in the preparation of other biologically active compounds. Written by internationally respected authors, the individual chapters explore beta-lactams’ synthesis, their mechanism of formation, biological effects, and function as base materials for other heterocycles of major importance.
Anti-idiotype antibodies in cancer treatment
Actively induced immunotherapy is one of the most promising fields in cancer research and numerous approaches are being studied to design effective cancer vaccines. Among the treatment strategies to develop an effective immune response against tumor associated antigens is the use of anti idiotype (Ab2) mAb as antigen surrogates. Several studies in animal models have demonstrated the efficacy of these vaccines for triggering the immune system to induce specific and protective immunity against tumors of different origin. In fact, anti-idiotypic mAbs have been used successfully in cancer therapeutics to overcome the poor immunogenicity of some tumor-associated antigens, in particular those of non-protein origin. In some clinical trials, including patients with different tumors, anti-Id specific humoral and/or cellular responses following immunization were associated with improved clinical outcome. This number of Frontiers will be dedicated to anti- idiotypic antibodies and their use in cancer treatment. Different article types will be considered: original contributions, case reports, methods, hypothesis and theory, reviews, historical, etc.
Peptides: The Wave of the Future
This volume contains the proceedings of the Second International Peptide Symposium and the Seventeenth American Peptide Symposium, held on 9-14 June, 2001, at the Town and Country Resort in San Diego, California. The biennial meeting was held under the auspices of the American Peptide Society. In addition to the main Symposium, we were honored to have the Merrifield Satellite Symposium, honoring Bruce Merrifield's accomplishments on his 80th birthday. Over 1250 participants from around the world attended the lectures, posters, and exhibits. Reflecting the international nature of the Symposium, there were participants from 37 countries in attendance. In addition to the 75 plenary lectures, there were over 575 poster presentations, and 70 commercial exhibits as well as booths from the American, Australian, Chinese, European, and Japanese Peptide Societies. These proceedings include plenary lectures and oral and poster presentations collected from a wide diversity of topics providing a truly comprehensive and up-to-date overview of the field of peptide science. This publication contains essential reference information for researchers active in peptide science.
Heterocyclic Scaffolds I
Contents: B. Alcaide ∙ P. Almendros: Novel Aspects on the Preparation of Spirocyclic and Fused Unsual β-Lactams.- S.S. Bari ∙ A. Bhalla: Spirocyclic β-Lactams: Synthesis and Biological Evaluation of Novel Heterocycles.- L. Troisi ∙ C. Granito ∙ E. Pindinelli: Novel and Recent Synthesis and Applications of β-Lactams.- C. Palomo ∙ M. Oiarbide: β-Lactams Ring Opening: A Useful Entry to Amino Acids and Relevant Nitrogen-Containing Compounds.- B. Mandal ∙ P. Ghosh ∙ B. Basu: Recent Approaches Towards Solid Phase Synthesis of β-Lactams.- A.Arrieta ∙ B. Lecea ∙ F.P. Cossio: Computational Studies on the Synthesis of β-Lactams Via [ 2+2] Thermal Cycloadditions.- B. K. Banik ∙ I. Banik ∙ F. F. Becker: Novel Anticancer β-Lactams
Hybrid Artificial Intelligent Systems, Part I
th The 5 International Conference on Hybrid Artificial Intelligence Systems (HAIS 2010) has become a unique, established and broad interdisciplinary forum for researchers and practitioners who are involved in developing and applying symbolic and sub-symbolic techniques aimed at the construction of highly robust and reliable problem-solving techniques, and bringing the most relevant achievements in this field. Overcoming the rigid encasing imposed by the arising orthodoxy in the field of arti- cial intelligence, which has led to the partition of researchers into so-called areas or fields, interest in hybrid intelligent systems is growing because they give freedom to design innovative solution...
Necrotrophic Fungal Plant Pathogens
Paloma Melgarejo is an author on one patent issued in Spain and one patent issued internationally, and has co-obtained plant variety rights for the following strawberry varieties: Aguedilla, Amiga, Carisma, Fontanilla, Fuentepina, Marina, Medina, and Santaclara. Maria Del Mar Jimenez-Gasco is an author on two patents issued in Spain, relating to the identification of Fusarium oxysporum.
Nucleic Acid Chemistry
This fourth part of a continuing series gives detailed information on up-to-date approaches that enable researchers to select suitable procedures. The descriptions provided are detailed so the novice, as well as those with experience, will be able to apply information in the laboratory.
Early Tejano Ranching
For two and a half centuries Tejanos have lived and ranched on the land of South Texas, establishing many homesteads and communities. This modest book tells the story of one such family, the Sáenzes, who established Ranchos San José and El Fresnillo. Obtaining land grants from the municipality of Mier in the Mexican state of Tamaulipas, these settlers crossed the Wild Horse Desert, known as Desierto Muerto, into present-day Duval County in the 1850s and 1860s. Through the simple, direct telling of his family’s stories, Andrés Sáenz lets readers learn about their homes of piedra (stone) and sillares (large blocks of limestone or sandstone), as well as the jacales (thatched-roof log huts...
