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Synthesis, Study and Utilization of Natural Products
Natural products and the preparations based on them play a stable and ever-increasing role in human and veterinary medicine, agriculture, in food and the cosmetic industry, and in an increasing number of other fields. Their importance is based on the fact that they are mostly bound to renewable sources, which in fact makes them valuable within a circular economy, inter alia. At the same time, natural products provide the origin of stereochemistry, optical activity, regioselectivity, chirality, and many other concepts and directions within science, development, and industry in a scope, which is indispensable. They serve as a constant powerful stimulus and model that inspires researchers to create new effective tools, similar to natural ones, for controlling bioregulation mechanisms and solving practical problems. This was the reason for organizing this Special Issue aimed at underlining the current developments in all the fields connected to natural products.
Cyclic Peptides
This book provides the reader with a comprehensive view of the state-of-the-art of cyclic peptides, from construction to utility in biology and drug discovery.
Ubiquitination in Health and Diseases
Ubiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which are profoundly related to human health and diseases. Although clinical applications targeting ubiquitination are still limited compared to those directed toward kinase systems such as tyrosine kinases, multiple enzymatic consequences should be future therapeutic implications. This Special Issue of IJMS entitled “Ubiquitination in Health and Disease” successfully published15 distinguished manuscripts, with a total of 66 international authors and. This book provides the latest and most useful information for researchers and scientists in this field.
The Japanese Economy
An introduction to the Japanese economy based on a comparative perspective and an analytic approach grounded in mainstream economics. It compares Japan with the United States in terms of economic performances, institutions and government policies and also scrutinizes the Japanese economy.
Advances in Biometrics
Recent advances in biometrics include new developments in sensors, modalities and algorithms. As new sensors are designed, newer challenges emerge in the algorithms for accurate recognition. Written for researchers, advanced students and practitioners to use as a handbook, this volume captures the very latest state-of-the-art research contributions from leading international researchers. It offers coverage of the entire gamut of topics in the field, including sensors, data acquisition, pattern-matching algorithms, and issues that impact at the system level, such as standards, security, networks, and databases
Numerical Astrophysics
These are the proceedings of international conference on Numerical As trophysics 1998 (NAP98), held at National Olympic Memorial Youth Cen ter, in Tokyo, Japan in the period of March 10 - 13, 1998, and hosted by the National Astronomical Observatory, Japan (NAOJ). In the last decade numerical simulations have grown up as a major tool for astrophysics. Numerical simulations give us invaluable informa tion on complex systems and physical processes under extreme conditions which can be neither realized by experiments nor directly observed. Super computers and special purpose computers may work as very large telescopes and special purpose telescopes for theoretical astrophysics, respectively. Nu...
Endothelins in Biology and Medicine
Endothelin-1 (ET-1), a peptide discovered in 1988, is one of the most potent contractors of vascular smooth muscle. Since their discovery, ETs have generated enormous interest in the scientific and pharmaceutical communities, prompting extensive research. This book addresses the latest findings regarding ETs-how they function, their effects, and characteristics. Divided into five sections, the book covers: endothelin receptors, endothelin synthesis and degradation, endothelin pathophysiology, ligand structure and activity relationships, and clinical studies. Pharmacologists, toxicologists, and pharmaceutical researchers will all benefit from this thorough review of current findings and future directions in ET research.
Organosulfur Chemistry in Asymmetric Synthesis
In this first book to gather the information on this hot topic otherwise widely spread throughout the literature, experienced editors and top international authors cover everything the reader needs -- from the synthesis of chiral organosulfur compounds to applications and catalysis: * Asymmetric synthesis of chiral sulfinates and sulfoxides * Synthesis and use of chiral dithioacetal derivatives, ylids, chiral sulfoximines and sulfinamides * Use of chiral sulfoxides as ligands in catalysis * Asymmetric reactions of alpha-sulfenyl, alpha-sulfinyl and alpha-sulfonyl carbanions. As a result, readers will be able to improve their own performance in asymmetric synthesis.
Advances in Genetics, Genomics and Control of Rice Blast Disease
Rice blast, caused by the fungal pathogen Magnaporthe grisea, is one of the most destructive rice diseases worldwide and destroys enough rice to feed more than 60 million people annually. Due to high variability of the fungal population in the field, frequent loss of resistance of newly-released rice cultivars is a major restraint in sustainable rice production. In the last few years, significant progress has been made in understanding the defense mechanism of rice and pathogenicity of the fungus. The rice blast system has become a model pathosystem for understanding the molecular basis of plant-fungal interactions due to the availability of both genomes of rice and M. grisea and a large collection of genetic resources. This book provides a complete review of the recent progress and achievements on genetic, genomic and disease control of the disease. Most of the chapters were presented at the 4th International Rice Blast Conference held on October 9-14, 2007 in Changsha, China. This book is a valuable reference not only for plant pathologists and breeders working on rice blast but also for those working on other pathysystems in crop plants.
