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Ubiquitination in Health and Diseases
Ubiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which are profoundly related to human health and diseases. Although clinical applications targeting ubiquitination are still limited compared to those directed toward kinase systems such as tyrosine kinases, multiple enzymatic consequences should be future therapeutic implications. This Special Issue of IJMS entitled “Ubiquitination in Health and Disease” successfully published15 distinguished manuscripts, with a total of 66 international authors and. This book provides the latest and most useful information for researchers and scientists in this field.
Cyclic Peptides
This book provides the reader with a comprehensive view of the state-of-the-art of cyclic peptides, from construction to utility in biology and drug discovery.
Synthesis, Study and Utilization of Natural Products
Natural products and the preparations based on them play a stable and ever-increasing role in human and veterinary medicine, agriculture, in food and the cosmetic industry, and in an increasing number of other fields. Their importance is based on the fact that they are mostly bound to renewable sources, which in fact makes them valuable within a circular economy, inter alia. At the same time, natural products provide the origin of stereochemistry, optical activity, regioselectivity, chirality, and many other concepts and directions within science, development, and industry in a scope, which is indispensable. They serve as a constant powerful stimulus and model that inspires researchers to create new effective tools, similar to natural ones, for controlling bioregulation mechanisms and solving practical problems. This was the reason for organizing this Special Issue aimed at underlining the current developments in all the fields connected to natural products.
The Japanese Economy
An introduction to the Japanese economy based on a comparative perspective and an analytic approach grounded in mainstream economics. It compares Japan with the United States in terms of economic performances, institutions and government policies and also scrutinizes the Japanese economy.
Mouse Models of Vascular Diseases
This book is a methodological source on mice models of vascular diseases. Covering various areas, each chapter is written by a pioneering researcher who has developed an original vascular disease model. Notoriously difficult to reproduce, each model is described in detail and numerous photographs are provided with links to videos. Genetically modified mice are a very powerful tool for studying the pathogenesis of various diseases, including immunological and oncological disorders, but they had always been thought to be too small to be used in the field of cardiovascular disease. Recently, however, various mice models of vascular diseases have been reported, and these will make a substantial contribution to basic research on cardiovascular and metabolic disorders.
Agriculture and Economic Growth
This book contains updated versions of a set of papers presented at the International Conference on Agriculture and Economic Development-A Symposium on Japan's Experience which was held in Tokyo, July, 1967. These papers make a comprehensive reappraisal of Japan's agricultural development and its relevance to economic growth over the last 100 years. They emphasize long-term studies in analyzing Japan's agricultural development, with the century following the Meiji Restoration as the historical setting. Intensive consideration is also given to the Meiji Era, 1868-1912. Part I considers the historical phases of Japan's development, and attempts to give a comprehensive exposition of Japan's lon...
Kidney and Blood Pressure Regulation
Chronic kidney disease is one of the world's major public health problems, and the prevalence of kidney failure is rising steadily. Among the risk factors for a faster progression of renal disease are hypertension and proteinuria, many studies clearly demonstrating that hypertension is both a cause and consequence of chronic kidney disease. Namely, renal blood pressure regulation seems to be involved in five major pathophysiological mechanisms (all closely related to the renin-angiotensin system): Pressure-natriuresis, renal sympathetic nervous system, renal blood flow, intraglomerular pressure and tubuloglomerular feedback. This book reviews experimental data which form the basis of our cur...
Advances in Biometrics
Recent advances in biometrics include new developments in sensors, modalities and algorithms. As new sensors are designed, newer challenges emerge in the algorithms for accurate recognition. Written for researchers, advanced students and practitioners to use as a handbook, this volume captures the very latest state-of-the-art research contributions from leading international researchers. It offers coverage of the entire gamut of topics in the field, including sensors, data acquisition, pattern-matching algorithms, and issues that impact at the system level, such as standards, security, networks, and databases
Numerical Astrophysics
These are the proceedings of international conference on Numerical As trophysics 1998 (NAP98), held at National Olympic Memorial Youth Cen ter, in Tokyo, Japan in the period of March 10 - 13, 1998, and hosted by the National Astronomical Observatory, Japan (NAOJ). In the last decade numerical simulations have grown up as a major tool for astrophysics. Numerical simulations give us invaluable informa tion on complex systems and physical processes under extreme conditions which can be neither realized by experiments nor directly observed. Super computers and special purpose computers may work as very large telescopes and special purpose telescopes for theoretical astrophysics, respectively. Nu...
