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Organic Chemistry
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Essays in Contemporary Chemistry
In this volume, internationally renowned chemists recount their roles in the progress of chemistry research toward elucidation of biological processes. Beginning with a historical perspective on the development of X-ray crystallography, the reader is regaled with first-hand accounts of research milestones. Included are descriptions of the cutting-edge nuclear-magnetic-resonance and electron-paramagnetic-resonance spectroscopic techniques, the dynamics of ultra-fast reactions, and the central problem of molecular oxygen activation in biological processes. The roles of chiral auxiliaries in organic synthesis and of photochemistry in natural product synthesis are told, and innovations in combin...
Perspectives in Nucleoside and Nucleic Acid Chemistry
The chemistry of nucleosides and nucleic acids is a rapidly developing field. Many of the most important recent advances in medicinal chemistry have occured in this field with the development of novel nucleoside– and nucleotide–based antiviral and antitumor drugs. New synthesis strategies involving novel protecting groups have helped spur progress in drug–development and genome–sequencing research. This volume, comprised of contributions written by internationally recognized experts, covers cutting–edge developments in current nucleoside and nucleic acid research. The most recent synthesis innovations, including combinatorial approaches, spectroscopy and structural studies, thermodynamic and computational investigations, stability assessments, and medicinal applications are presented. Synthetic, physical, organic, bioorganic, and medicinal chemists working on all aspects of nucleoside and nucleic acid research will value this comprehensive state–of–the–art overview.
Highlights of Chemistry
This book provides a comprehensive overview of more than 75 years of Swiss chemical research. Leading authors, among them L. M. Venanzi, H. Zollinger, E. Heilbronner and J. D. Dunitz, highlight outstanding pieces of research that have appeared in Helvetica Chimica Acta since its foundation, in 1917. This collection of highly readable essays will be of great interest to chemists, historians of chemical science, and anyone who wants to know more about the exciting development of Swiss chemistry in the twentieth century.
Hominatio
The historical achievements in organic natural product synthesis can be recognized most clearly in the research accomplishments of Albert Eschenmoser. For example, his work on the chemical synthesis of vitamin B12 defined the frontier in organic natural product synthesis and profoundly influenced the science of organic chemistry. In addition to revealing the beautiful reaction pathways leading to compounds of great biochemical significance, Albert Eschenmoser has contributed innovative methods of outstanding utility for organic synthesis. Few individuals have so fundamentally influenced the science of organic chemistry as Albert Eschenmoser has. Over the years, a sizable fraction of Albert E...
Organic Chemistry: Its Language and Its State of the Art
A unique depiction of the language and state-of-the-art of organic chemistry. This book is a collection of essays based on contributions to the international commemorative symposium on the centennial anniversary of the 'Geneva Conference'. Distinguished chemists - among them J.-M. Lehn, J. Dunitz, L. A. Paquette, W. Oppolzer, L. Hegedus and V. Prelog - examine the history and diversity of modern organic chemistry. The book is also a fascinating exploration of the intricate relationship between language and progress in chemistry.
The Cambridge History of Science: Volume 5, The Modern Physical and Mathematical Sciences
A new and comprehensive examination of the history of the modern physical and mathematical sciences.
Hydrolysis in Drug and Prodrug Metabolism
Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.
Origin of Life
Dedicated to one of the great pioneers of this science, Leslie Orgel, on the occasion of his 80th birthday, this compilation of reviews and original manuscripts provides an overview of the current state of the art, written by some of the major players in this creative domain of 'explorative chemistry' (such as Christian De Duve, Albert Eschenmoser, Gunter Wachtershauser). Since we are still far from finding a definitive answer to the most fundamental of questions in science, 'chemistry' here is defined in its broadest sense. It is against ...
