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Carotid Body: A New Target for Rescuing Neural Control of Cardiorespiratory Balance in Disease
The carotid body (CB) is in charge of adjusting ventilatory and cardiovascular function during changes in arterial blood gases. Regardless this essential function, the CB has been implicated in the sensing of other physiological signals such as changes in blood flow and glucose levels. More important, malfunction of the CB chemoreceptors has been associated with the progression and deterioration of several disease states such as hypertension, heart failure, renal failure, insulin resistance, diabetes and sleep apnea. Although the mechanisms involved in the alterations of the CB function in pathophysiology are currently under intense research, the development of therapeutic approaches to rest...
The University Becoming
This volume wholeheartedly engages with the current climate in higher education and provides not only a thorough analysis of the foundational elements constituting higher education but also a critical discussion of possible connections to societal and cultural domains and policy debates. Today, higher education institutions and programs are beset with multiple, and often conflicting, pressures and demands. Higher education is regarded by societies in general, and at the political level in particular, as a pathway to securing continued economic growth and ensuring cultural growth in surrounding societal contexts. Future academics are expected to become experts within their disciplines and at ...
Encounterism: The Neglected Joys of Being In Person
A playful, analytical, informed, and poetic exploration of the delight and transformative power of real-life encounters. The light touch of a hairdresser’s hands on one’s scalp, the euphoric energy of a nightclub, huddling with strangers under a shelter in the rain, a spontaneous snowball fight in the street, a daily interaction with a homeless man—such mundane connections, when we closely inhabit the same space, and touch or are touched by others, were nearly lost to “social distancing.” Will we ever again shake hands without a thought? In this deeply rewarding book, Andy Field brings together history, science, psychology, queer theory, and pop culture with his love of urban life and his own experiences—both as a city-dweller and as a performance artist—to forge creative connections: walking hand-in-hand with strangers, knocking on doors, staging encounters in parked cars. In considering twelve different kinds of encounters, from car rides to video calls to dog-walker chats in the park, Field argues “that in the spontaneity and joy of our meetings with each other, we might find the faint outline of a better future.”
Participatory Practice in Space, Place, and Service Design
'Participatory Practice in Space, Place, and Service Design' is premised on a belief in the importance of participatory practices in finding creative solutions to the plethora of problems we face today. It argues that engaging professions with the public in mutual exploration, analysis, and creative thinking is essential. It not only ensures better quality products, places, services, and a greater sense of civic agency but also facilitates fuller access to them and the life opportunities they can unleash. This book offers a uniquely varied perspective of the myriad ways in which participatory practices operate across disciplines and how they impact the worlds and communities we create and in...
Mathematics for Healthcare
In 1996, and with extraordinary prescience, Panfilov and Holden had highlighted in their seminal book 'Computational Biology of the Heart' that biology was, potentially, the most mathematical of all sciences. Fast-forward 20 years and we have seen an explotion of applications of mathematics in not only biology, but healthcare that has already produced significant breakthroughs not imaginable more than 20 years ago. Great strides have been made in explaining through quantitative methods the underlying mechanisms of human disease, not without considerable ingenuity and effort. Biological mechanisms are bewildering: complex, ever evolving, multi-scale, variable, difficult to fully access and un...
The Existential Toolkit for Climate Justice Educators
An easy-to-use field guide for teaching on climate injustice and building resilience in your students—and yourself—in an age of crisis. As feelings of eco-grief and climate anxiety grow, educators are grappling with how to help students learn about the violent systems causing climate change while simultaneously navigating the emotions this knowledge elicits. This book provides resources for developing emotional and existential tenacity in college classrooms so that students can stay engaged. Featuring insights from scholars, educators, activists, artists, game designers, and others who are integrating emotional wisdom into climate justice education, this user-friendly guide offers a robust menu of interdisciplinary, plug-and-play teaching strategies, lesson plans, and activities to support student transformation and build resilience. The book also includes reflections from students who have taken classes that incorporate their emotions in the curricula. Galvanizing and practical, The Existential Toolkit for Climate Justice Educators will equip both educators and their students with tools for advancing climate justice.
Function of Renal Sympathetic Nerves
Sympathetic overactivity is associated with the development of hypertension. Renal denervation (RDN) prevents or delays hypertension in a variety of animal models, which laid the groundwork for the introduction of RDN as a clinical therapy in humans. In 2007, a novel, minimally invasive RDN ablation catheter was first trialled in hypertensive patients, with a 93% success rate of lowering blood pressure for at least three years post-RDN. However, a large scale, sham-controlled clinical trial (Symplicity HTN -3) failed to show reductions in BP greater than sham. The aim of this research topic was to evaluate the efficacy and safety of RDN, to explore the contribution of both afferent and efferent renal nerve activity to hypertension and non-hypertension disorders, and to stimulate future research to better understand the function of the renal nerves and the effects of RDN by highlighting gaps in knowledge.
The Playful University
This book provides philosophical, political and practical insights that open ways for the university in going beyond its tightly controlled state and into more playful and imaginative futures. In the context of a marketised and regulated environment that stifles creativity and curiosity in higher education, this collection provides an antidote that lies in the potential of play. It identifies tactics and tools for playful practices to conjure real utopias and pathways for the present and possible futures. Pulling together global perspectives from a wide array of different disciplines including higher education, sociology, philosophy, media studies, design, literature, play studies, game stud...
Hypoxia in Kidney Disease
Kidney disease is a complex health problem, often coinciding with cardiovascular pathology (e.g. hypertension) and metabolic disturbances (e.g. obesity and diabetes). It is also a disturbingly fast growing global public health problem, e.g. chronic kidney disease affects an estimated ~9-16% of the population. Besides the public health issues this results in a large economic burden as kidney diseases contributes disproportionally to about a quarter of total health care costs. Experimental and clinical data solidly support the view that kidney tissue hypoxia plays a critical and intricate role during the genesis and progression of both chronic and acute kidney diseases. This research field is ...
