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The new edition of this atlas integrates all significant advances made in the past 15 years in molecular pathology, tumor virology, and genetics of cervical cancer. It emphasizes the importance of these advances in facilitating its pathological diagnosis and in op- mizing clinical management and prognosis. A new chapter on immunohistochemistry has been added, which includes refined detection methods, e. g., the overexpression of INK4a p16 as a molecular marker in the early differential diagnosis of premalignant - sions. The section on etiology and pathogenesis in human papillomavirus-induced neoplasia has been incorporated to represent new insights into the sequences of cel- lar and nuclear ...
Volume 68 of Advances in Cancer Research continues the tradition of publishing up-to-date reviews and "hot" topics in cancer research. This volume begins with a "Foundations in Cancer Research" article by Harald zur Hausen that reviews his years of research on the idea that cancer can be triggered by infection. The structure and function of the cytokine receptor superfamily and its association with leukemias are discussed in depth by James Ihle. Marcia Hall and Gordon Peters review the evidence indicating that genetic abnormalities hinder the function of certain cyclins and their inhibitors. The most widely studied protooncogene, c-myc, is reviewed by Marie Henriksson and Bernhard Lüscher; the chapter focuses on the function of c-myc as a transcription factor rather than on the effects of gene translocation and activation on malignancies. Ham Werner and Derek LeRoith present data on the role that insulin-like growth factors play on cell growth and regulation. In the final chapter, Olli-P. Kallioniemi and Tapio Visakorpi investigate the field of prostate cancer and, more importantly, the biological reason and natural history behind the growth of this cancer.
Providing a concise update of the current knowledge on human papillomavirus (HPV) infections and their intimate link to cervical cancer, the book focuses on five interrelated topics: high- and low-risk HPV infections, methods for HPV detection and use of
Contains twelve articles which explore the epidemiology of HPV, testing strategies for HPV infections, new HPV detection methods and other potential biomarkers that might prove useful in cervical cancer diagnosis. This book includes articles which address the research on biomarkers for cervical cancer.
The Cancer Biomarkers Research Group (CBRG) of the Division of Cancer Prevention (DCP), National Cancer Institute, sponsored a workshop entitled Molecular Signatures of Infectious Agents in Bethesda, Maryland, September 7 - 8, 2000, to identify molecular signatures of infectious agents and to utilize this information for risk assessment and development of prevention strategies against these infectious agents. The specific objectives of the workshop were to review state-of-the-science in detection technology that can identify extraneous genomic insertion in human cancers and to establish future research directions for using the molecular signatures of infectious agents for early detection, risk assessment and prevention of cancer.
Includes abstracts of papers of various symposia.
Intelligence allows people to understand events and to shape their surrounding environment. This book delves deeper into the theories and applications of intelligence, showing it is a multifaceted concept —defined and explained differently by prestigious experts of various disciplines in their own research. The book provides interdisciplinary connections of intelligence as it relates to a variety of clearly outlined subject areas, and should lead to a deep understanding of the phenomenon as it pertains to practical applications in different domains. Contributors in this volume present results from evolutionary biology, mathematics, artificial intelligence, medicine, psychology, cultural studies, economy, political sciences and philosophy. Individual scientific models are integrated in an interdisciplinary concept of wisdom. This volume will help enhance the common understanding of intelligence for fellow researchers and scientists alike.