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How does a mere molecule—a chemical structure—become a drug? And, how do we know that it works safely? In a one-trillion-dollar pharmaceutical industry with high-stakes profits and perils, battles are raging every day to successfully bring a molecule to its birth: an FDA-approved medicine. In Race for a Remedy, internationally renowned expert in cancer treatment and drug development Makhdum Ahmed, MD, takes readers behind the scenes of the fascinating and intense world of cancer drug development. Whether it’s a small molecule, a versatile monoclonal antibody, or the fancy, poster child of cutting-edge cell therapy, modern drugs are built upon a centuries-old solid foundation set by the...
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Eleventh in a series of annual reports comparing business regulations in 189 economies, Doing Business 2014 measures regulations affecting 11 areas of everyday business activity around the world.
Twelfth in a series of annual reports comparing business regulation in 189 economies, Doing Business 2015 measures regulations affecting 10 areas of everyday business activity: Starting a business Dealing with construction permits Getting electricity Registering property Getting credit Protecting minority investors Paying taxes Trading across borders Enforcing contracts Resolving insolvency Labor market regulations This year's report will present data for a second city for the 11 economies with more than 100 million inhabitants. These are Bangladesh, Brazil, China, India, Indonesia, Japan, Mexico, Nigeria, Pakistan, the Russian Federation, and the United States. Three of the 10 topics covere...
The idea of Pakistan stands riddled with tensions. Initiated by a small group of select Urdu-speaking Muslims who envisioned a unified Islamic state, today Pakistan suffers the divisive forces of various separatist movements and religious fundamentalism. A small entrenched elite continue to dominate the country’s corridors of power, and democratic forces and legal institutions remain weak. But despite these seemingly insurmountable problems, the Islamic Republic of Pakistan continues to endure. The Pakistan Paradox is the definitive history of democracy in Pakistan, and its survival despite ethnic strife, Islamism and deepseated elitism. This edition focuses on three kinds of tensions that are as old as Pakistan itself. The tension between the unitary definition of the nation inherited from Jinnah and centrifugal ethnic forces; between civilians and army officers who are not always in favour of or against democracy; and between the Islamists and those who define Islam only as a cultural identity marker.