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Tendon Healing
Mechanical loading and the inflammatory response during tendon healing might be important for the healing process. Mechanical loading can improve the healing tendon but the mechanism is not fully understood. The aim of this thesis was to further clarify the effect of mechanical loading on tendon healing and how mechanical loading affects the inflammatory response during the healing process. We used a rat Achilles tendon model to study healing. The rats were exposed to different degrees of loading by unloading methods such as paralysis of the calf muscles with Botox, tail suspension, and an orthosis (a boot). Full loading was achieved by free cage activity or treadmill walking. Microdamage in...
Aseptic Loosening of Orthopedic Implants
Aseptic loosening is the main cause of failure of orthopedic prostheses. With no pharmaceuticals to prevent or mitigate periprosthetic bone degradation, a surgery to replace the loose implant with a new one is the only choice to restore patients’ function. Most studies on mechanisms for aseptic loosening investigate wear debris particle-induced osteolysis. However, pathological loading conditions around unstable implants can also trigger osteoclast differentiation and bone loss. In the first study, global gene expression changes induced by mechanical instability of implants, and by titanium particles were compared in a validated rat model for aseptic loosening. Microarray analysis showed t...
Inflammation and tendon healing
Tendons heal through three different overlapping phases; the inflammatory, proliferative and remodeling phase. Many studies have investigated what factors influence healing of tendons. However, little was known about inflammation and the immune cells present during Achilles tendon healing by the time this thesis started. We developed a flow cytometry method for our rat model of tendon healing, which enabled us to study different leukocyte subpopulations during Achilles tendon healing. The general aim of this thesis was to understand more about inflammation and the immune cell populations present during tendon healing and how the immune cell composition changes during normal tendon healing. M...
Inflammation in Cancellous and Cortical Bone Healing
Fractures in humans most commonly occur near the joints, in the metaphyseal bone area mainly consisting of cancellous bone. Despite this, mainly cortical fractures, located in the diaphyseal bone area, have been studied in experimental models of bone healing. It is known from previous studies that the diaphyseal fracture is sensitive to anti-inflammatory treatment, while metaphyseal bone healing is more resistant. The aim of this thesis is to study the inflammatory response to bone trauma in cancellous and cortical bone. A flow cytometric method was established for the purpose of examining the cellular composition of the inflammatory process in models of bone healing In paper I the cellular ...
Mechanisms of mechanically induced Osteoclastogenesis
Total joint arthroplasty is the primary intervention in the treatment of end-stage osteoarthritis. Despite the high success rate, in some patients, the replacement will fail during their lifetime requiring a revision of the implant. These revisions are strenuous for the patient and costly for health care. Joint replacement at a younger age, in combination with a more active lifestyle, increases the need for an early revision of the joint prosthesis. The main reason for revision surgeries is aseptic loosening, a condition where the prosthesis is loosening due to bone degradation at the peri-prosthetic interface in the absence of infections. The most well-established pathological mechanism for...
Books Across Borders
Books Across Borders: UNESCO and the Politics of Postwar Cultural Reconstruction, 1945-1951 is a history of the emotional, ideological, informational, and technical power and meaning of books and libraries in the aftermath of World War II, examined through the cultural reconstruction activities undertaken by the Libraries Section of the United Nations Educational, Scientific and Cultural Organization (UNESCO). The book focuses on the key actors and on-the-ground work of the Libraries Section in four central areas: empowering libraries around the world to acquire the books they wanted and needed; facilitating expanded global production of quality translations and affordable books; participating in debates over the contested fate of confiscated books and displaced libraries; and formulating notions of cultural rights as human rights. Through examples from France, Poland, and surviving Jewish Europe, this book provides new insight into the complexities and specificities of UNESCO’s role in the realm of books, libraries, and networks of information exchange during the early postwar, post-Holocaust, Cold War years.
Covid Babies
As the Covid-19 pandemic took hold, pregnancy and maternity services underwent a rapid transformation in an attempt to deal with transmission of the virus and the growing pressure on healthcare services. In a climate of fear, and with many unknowns about the virus and the risks to pregnant women and their babies, restrictions and hastily implemented policies often overrode years of work to improve maternity care, with devastating consequences for new families. Covid Babies: how pandemic health measures undermined pregnancy, birth and early parenting considers how policies put in place to protect us from the immediate threat of the virus ultimately had the unintended consequence of harming ma...
