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Updates in Pharmacogenetics of Non-Small Cell Lung Cancer
Though significant clinical advances have been made, lung cancer remains the most lethal, with a low 5-year survival rate. The variability in patient response towards therapy is substantial and is associated with lung cancer,Äôs genomic landscape. Pharmacogenetic studies have deciphered many clinically relevant associations between tumor genetic alterations and their influences on drug efficacy, toxicity sensitivity and overall outcomes of cancer treatment. Biomarkers are tools in the arsenal that can help in the prediction, prognosis, diagnosis and follow-up of cancer treatment. Bulk and single-cell next-generation sequencing of large patient cohorts have generated a better understanding ...
Extracellular Vesicles
This edited volume, Extracellular Vesicles - Applications and Therapeutic Potential, provides a comprehensive overview of the emerging data confirming the involvement of extracellular vesicles (EVs) in disease development. It also discusses the scientific advancements that have enabled the characterization and manipulation of EVs, leading to their utilization as tools in biomarker discovery, disease diagnosis, prognosis, and therapeutic interventions. The book examines the latest research efforts in the field by international authors and opens new possible research paths for further novel developments.
Extracellular Vesicles
Extracellular vesicles (EVs) are nanoscale vesicles secreted by cells that mediate horizontal cargo transport from donor to recipient cell, thereby establishing cell-cell communication and signaling. This book provides critical information on the fundamentals of EVs, their roles in diseases like cancer, and their use in disease management. The chapters emphasize the emerging data confirming the role of EVs in the pathogenesis of diseases and discuss the scientific advances that have made it feasible to characterize and engineer EVs, leading to their use as tools in biomarker discovery and disease diagnosis, prognosis, therapeutic application, and theranostics. This volume is a valuable resource for basic biologists, translational scientists, and clinicians.
Organoid Bioengineering
Organoids are three-dimensional miniature tissue mimics established from embryonic stem cells, human pluripotent stem cells, adult stem cells, and cancer cells. These fascinating 3D organoids serve as a valuable tool for fundamental research, disease modeling, drug screening and discovery, regenerative medicine, and deciphering the mechanism of disease pathogenesis. This book emphasizes the emerging data and critical resources covering the fundamentals of organoids and their use in modeling and application in various diseases, especially cancer. The chapters deal with organoid bioengineering in cerebral organoids, retinal organoids, tumoroids, and organoid commercialization. This book is intended for a broad readership and is an indispensable resource for basic biologists, translational scientists, and clinicians.
Cell Culture
Cell culture is cell cloning technology that simulates in vivo environment conditions such as asepsis, appropriate temperature, and pH as well as certain nutritional conditions to enable cells to survive, grow, reproduce, and maintain their structure and function. Cell culture can be used to grow human, animal, plant, and microbial cells. Each type of cell culture has its own characteristics and essential conditions. This book focuses on the advanced technology and applications of cell culture in the research and practice of medical and life sciences. Chapters address such topics as primary cancer cell cultures, 2D and 3D cell cultures, stem cells, nanotechnology, and more.
Pharmacogenetics
Pharmacogenetics is the study of the effects of individual genetics on drug responses. This book provides an overview of the current state of the pharmacological genetic aspects of these treatments. It discusses drugs with genetic information to support product labeling, clinical guidelines, or significant mechanical effects. Pharmacogenetic studies have also allowed us to better understand the pharmacology of medications used to treat neurologic and psychiatric disorders. This book also reviews the current state of the science and potential clinical utility of pharmacogenetic markers for these treatments. Furthermore, it highlights the in silico approach as a promising tool for further research on experimental pharmacology.
Revolutionizing Healthcare Through Artificial Intelligence and Internet of Things Applications
Medical internet of things (IoT)-based applications are being utilized in several industries and have been shown to provide significant advantages to users in critical health applications. Artificial intelligence (AI) plays a key role in the growth and success of medical IoT applications and IoT devices in the medical sector. To enhance revenue, improve competitive advantage, and increase consumer engagement, the use of AI with medical IoT should be encouraged in the healthcare and medical arena. Revolutionizing Healthcare Through Artificial Intelligence and Internet of Things Applications provides greater knowledge of how AI affects healthcare and medical efficacy in order to improve outputs. It focuses on a thorough and comprehensive introduction to machine learning. Covering topics such as patient treatment, cyber-physical systems, and telemedicine, this premier reference source is a dynamic resource for hospital administrators, medical professionals, government officials, students and faculty of higher education, librarians, researchers, and academicians.
Organoids and Commercialization
Organoids are 3D miniature tissue mimics and have been effectively used for various purposes, including disease modeling, various drug screening, mechanism of pathogenesis, stem cell research, and tumor immunology. Organoids are as varied as the body,Äôs tissues and organs and have enormous economic potential. They can open new ways to tailored therapy and precision medicine. In clinical investigations, patient-derived organoids have been used to predict patient responses to therapeutic regimens and perhaps improve cancer treatment outcomes. Recent developments in stem cell research and genomic technologies have led to breakthrough innovations in organoid bioengineering, large-scale manufacturing, biobanking, and commercialization. This chapter reviews the notion of organoid biobanking, companies involved and the commercialization aspect, and ethical considerations.
