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Computational analysis of natural science experiments often confronts noisy data due to natural variability in environment or measurement. Drawing conclusions in the face of such noise entails a statistical analysis. Parametric statistical methods assume that the data is a sample from a population that can be characterized by a specific distribution (e.g., a normal distribution). When the assumption is true, parametric approaches can lead to high confidence predictions. However, in many cases particular distribution assumptions do not hold. In that case, assuming a distribution may yield false conclusions. The companion book Statistics is Easy, gave a (nearly) equation-free introduction to nonparametric (i.e., no distribution assumption) statistical methods. The present book applies data preparation, machine learning, and nonparametric statistics to three quite different life science datasets. We provide the code as applied to each dataset in both R and Python 3. We also include exercises for self-study or classroom use.
This book introduces complex analysis and is appropriate for a first course in the subject at typically the third-year University level. It introduces the exponential function very early but does so rigorously. It covers the usual topics of functions, differentiation, analyticity, contour integration, the theorems of Cauchy and their many consequences, Taylor and Laurent series, residue theory, the computation of certain improper real integrals, and a brief introduction to conformal mapping. Throughout the text an emphasis is placed on geometric properties of complex numbers and visualization of complex mappings.
A problem factory consists of a traditional mathematical analysis of a type of problem that describes many, ideally all, ways that the problems of that type can be cast in a fashion that allows teachers or parents to generate problems for enrichment exercises, tests, and classwork. Some problem factories are easier than others for a teacher or parent to apply, so we also include banks of example problems for users. This text goes through the definition of a problem factory in detail and works through many examples of problem factories. It gives banks of questions generated using each of the examples of problem factories, both the easy ones and the hard ones. This text looks at sequence extension problems (what number comes next?), basic analytic geometry, problems on whole numbers, diagrammatic representations of systems of equations, domino tiling puzzles, and puzzles based on combinatorial graphs. The final chapter previews other possible problem factories.
This is the second part of our book on continuous statistical distributions. It covers inverse-Gaussian, Birnbaum-Saunders, Pareto, Laplace, central 2, , , Weibull, Rayleigh, Maxwell, and extreme value distributions. Important properties of these distribution are documented, and most common practical applications are discussed. This book can be used as a reference material for graduate courses in engineering statistics, mathematical statistics, and econometrics. Professionals and practitioners working in various fields will also find some of the chapters to be useful. Although an extensive literature exists on each of these distributions, we were forced to limit the size of each chapter and ...
Fleshy Fruits are a late acquisition of plant evolution. In addition of protecting the seeds, these specialized organs unique to plants were developed to promote seed dispersal via the contribution of frugivorous animals. Fruit development and ripening is a complex process and understanding the underlying genetic and molecular program is a very active field of research. Part of the ripening process is directed to build up quality traits such as color, texture and aroma that make the fruit attractive and palatable. As fruit consumers, humans have developed a time long interaction with fruits which contributed to make the fruit ripening attributes conform our needs and preferences. This issue ...
One of the goals of plant science is to improve agricultural sustainability, increasing yield, food diversity, and nutrition, while minimizing the negative impact on our environment. In response to internal and external cues, plant hormones control various aspects of plant growth and development. The wealth of our knowledge on plant hormones shall greatly advance sustainable agriculture.
This volume aims to provide a timely view of the state-of-the-art in systems biology. The editors take the opportunity to define systems biology as they and the contributing authors see it, and this will lay the groundwork for future studies. The volume is well-suited to both students and researchers interested in the methods of systems biology. Although the focus is on plant systems biology, the proposed material could be suitably applied to any organism.
Papers presented at national seminar held during 17th-18th March, 2017 at Centre for Economic Studies, Central University of Punjab, Bathinda, India.
This updated volume provides stepwise instructions for the analysis of numerous clinically important analytes by mass spectrometry. Mass spectrometry offers clinical laboratory scientists a number of advantages including increased sensitivity and specificity, multiple component analysis, and limited need for specialized reagents. These techniques are essential in laboratory fields including endocrinology, biochemical genetics, drug analysis, proteomics, and pathogen identification. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Clinical Applications of Mass Spectrometry in Biomolecular Analysis: Methods and Protocols, Second Edition is an ideal resource for clinical laboratory scientists who are already using or thinking of bringing mass spectrometry to their laboratories.
The computational education of biologists is changing to prepare students for facing the complex datasets of today's life science research. In this concise textbook, the authors' fresh pedagogical approaches lead biology students from first principles towards computational thinking. A team of renowned bioinformaticians take innovative routes to introduce computational ideas in the context of real biological problems. Intuitive explanations promote deep understanding, using little mathematical formalism. Self-contained chapters show how computational procedures are developed and applied to central topics in bioinformatics and genomics, such as the genetic basis of disease, genome evolution or the tree of life concept. Using bioinformatic resources requires a basic understanding of what bioinformatics is and what it can do. Rather than just presenting tools, the authors - each a leading scientist - engage the students' problem-solving skills, preparing them to meet the computational challenges of their life science careers.