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Pulmonary Hypertension
Written by internationally recognized experts, Pulmonary Hypertension bridges the gap between pulmonology and cardiology to provide clinicians in both disciplines with knowledge of the signs, symptoms, diagnosis, and pharmacologic and surgical treatments for pulmonary hypertension (PH). Through the use of clinical trials, this ground-breaking text supplies a comprehensive review of both the primary and secondary clinical and investigative aspects of this condition. Discussing controversies and concepts in PH diagnosis and management, this guide explores: classification and epidemiology, pathology, pathogenesis, genetics, and diagnosis of PH causes of the condition, such as idiopathic pulmonary arterial hypertension (IPAH) PAH-complicating connective tissue diseases (CTD), congenital heart diseases, human immunodeficiency virus (HIV), and other disorders the mechanisms, toxicities, and efficacy of therapeutic agents the role of combination therapies, novel agents, and future directions PH in specific patient populations such as pregnant and critically-ill patients in the ICU
Pharmacotherapy of Pulmonary Hypertension
This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this area. The first part of the book covers the definition, classification, pathophysiology, pathology, biomarkers and animal models of the disease, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The last section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotide homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to the clinical applications of these experimental therapies, that are on the horizon. The book thus spans the continuum from basic science to clinical applications.
ERS Handbook of Respiratory Medicine
The European Respiratory Society (ERS) Handbook of Respiratory Medicine, now in its third edition, is a concise, compact and easy-to-read guide to each of the key areas in respiratory medicine. Its 20 sections, written by clinicians and researchers at the forefront of the field, explain the structure and function of the respiratory system, its disorders and how to treat them. The Handbook is a must-have for anyone who intends to remain up to date in the field, and to have within arm's reach a reference that covers everything from the basics to the latest developments in respiratory medicine.
Pulmonary Circulation
Authoritative, comprehensive and definitive, Pulmonary Circulation builds on the success of its previous two editions by providing practising respiratory physicians with a highly-ordered, unique reference work on the structure, function and pathophysiology of the pulmonary circulation. New for the third edition: Thoroughly revised with comprehensive coverage from diagnosis and clinical evaluation of pulmonary hypertension, to imaging techniques, disorders and treatment A new truly global team of expert editors, authors and key opinion leaders provide a wealth of detail on the latest developments and issues New chapters, such as: paediatrics, critical care, special environments including high altitude and underwater More quality chapters, authors, illustrations with thorough and thoughtful referencing make this book a contemporary essential reference text Pulmonary Circulation remains an essential resource for pulmonary hypertension specialists and should prove invaluable in all respiratory, cardiac and intensive care units.
Severe Asthma
Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.
The Challenges of Educating People to Lead in a Challenging World
This volume explores the challenges of educating professionals to succeed in a complex, uncertain and global business world. The book contains intellectual concepts and practical advice from leaders in innovative education around the globe. It will help educators and the educational enterprise become more innovative, efficient, and effective in addressing the teaching/learning challenges associated with helping students prepare to face their own challenges.
The Sum of It All
Lewis E. Lehrman’s biography recounts a purposeful life of accomplishments. He was instrumental early on in building up the family business, Rite Aid. Later he formed a successful investment business, joined Morgan Stanley, and founded a hedge fund. To further his passion for study, he founded the Lehrman Institute and, with Richard Gilder, the Gilder Lehrman Institute of American History, receiving the National Humanities Medal in 2005 for their groundbreaking work in history. Lehrman endowed the Lincoln Prize, partnered with Monticello, and created the Gilder Lehrman Center for the Study of Slavery, Resistance, and Abolition at Yale. His significant collection of historical documents and...
The Right Heart
This heavily revised second edition of this critical book details the structure, function and imaging of the normal right heart both at rest and under the stresses of high altitude and exercise. Extensively revised chapters cover the pathophysiology and pathobiology of right heart dysfunction, both in experimental models and human disease, including congenital heart disease and pulmonary hypertension. The Right Heart provides a concise up-to-date guide on the latest advances in our understanding of role of the right heart in the cardiopulmonary circuit and is an indispensable up-to-date resource for clinicians interested in this topic.
News Agencies from Pigeon to Internet
Deals with a very important business in global communication of news -- the news agencies. The first news agencies started their business when the fastest technology was a combination of telegraph and carrier pigeon. They have survived several technological developments since then and have used these technologies for further diversification of services and revenues. The Internet, some thought, will make the news agencies extinct like dinosaurs. But, well run news agencies found a new opportunity in this threat. Though there have been some corporate biographies of news agencies, there has not been any comprehensive analytical work in the past 25 years on this business. This book is an attempt to fill this void in the global literature on journalism, media studies, international communication and business management studies. Besides, the students of these academic disciplines, diplomats, policymakers, and all types of communication professionals will find this book useful. It will also be a good read for lay persons who unconsciously consume the products of news agencies through all types of media -- from newspapers to mobile phones.
Management of Acute Pulmonary Embolism
This practical volume highlights traditional, novel, and evolving aspects of the diagnosis and treatment of pulmonary embolism (PE). The contributors comprise an international team of experts. Important aspects of diagnosis, risk stratification, and differential treatment of patients with PE are presented in a concise, yet comprehensive manner. Emphasis is placed on specific issues related to PE, including pregnancy, cancer, thrombophilia, and air travel.
