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Neuromodulation for Intractable Pain
Over 7% of the Western population suffers from intractable pain. Despite pharmacotherapy, many patients (1.5%) suffer from refractory pain. In addition to the pain, patients continue to be highly debilitated and suffer from depression and anxiety, poor quality of life and loss of employment. An ever enlarging global problem concerns the use of opiates which have risen to dangerous levels. Neuromodulation of the nervous system—where the function of the nervous system is altered by a device—has, over time, emerged as an effective alternative to pharmacotherapy in the management of these patients. In this Special Issue, we discussed the indications, safety, efficacy, mechanisms of action and other aspects of neurmodulation therapies for pain relief. These include peripheral nerve stimulation, peripheral field stimulation, spinal cord stimulation, dorsal root ganglion stimulation, motor cortex stimulation and deep brain stimulation. We do not intend this Special Issue to be a comprehensive study of pain but a guide to help clinicians to refer patients appropriately and to decide which procedure would best be offered in certain situations.
Advances in Autism Research
This book represents one of the most up-to-date collections of articles on clinical practice and research in the field of Autism Spectrum Disorders (ASD). The scholars who contributed to this book are experts in their field, carrying out cutting edge research in prestigious institutes worldwide (e.g., Harvard Medical School, University of California, MIND Institute, King’s College, Karolinska Institute, and many others). The book addressed many topics, including (1) The COVID-19 pandemic; (2) Epidemiology and prevalence; (3) Screening and early behavioral markers; (4) Diagnostic and phenotypic profile; (5) Treatment and intervention; (6) Etiopathogenesis (biomarkers, biology, and genetic, ...
Geometric Methods in PDE’s
The analysis of PDEs is a prominent discipline in mathematics research, both in terms of its theoretical aspects and its relevance in applications. In recent years, the geometric properties of linear and nonlinear second order PDEs of elliptic and parabolic type have been extensively studied by many outstanding researchers. This book collects contributions from a selected group of leading experts who took part in the INdAM meeting "Geometric methods in PDEs", on the occasion of the 70th birthday of Ermanno Lanconelli. They describe a number of new achievements and/or the state of the art in their discipline of research, providing readers an overview of recent progress and future research trends in PDEs. In particular, the volume collects significant results for sub-elliptic equations, potential theory and diffusion equations, with an emphasis on comparing different methodologies and on their implications for theory and applications.
Harmonic Analysis and Operator Theory
The collection covers a broad spectrum of topics, including: wavelet analysis, Haenkel operators, multimeasure theory, the boundary behavior of the Bergman kernel, interpolation theory, and Cotlar's Lemma on almost orthogonality in the context of L[superscript p] spaces and more...
Advances in Multiple Sclerosis Research—Series I
Designing immunotherapeutics, drugs, and anti-inflammatory reagents has been at the forefront of autoimmune research, in particular multiple sclerosis, for over 20 years. Delivery methods that are used to modulate effective and long-lasting immune responses have been the major focus. This Special Issue focused on delivery methods to be used for vaccines, immunotherapeutic approaches, drug design, and anti-inflammatories and their outcomes in preclinical studies and clinical trials.
Nonsmooth Differential Geometry-An Approach Tailored for Spaces with Ricci Curvature Bounded from Below
The author discusses in which sense general metric measure spaces possess a first order differential structure. Building on this, spaces with Ricci curvature bounded from below a second order calculus can be developed, permitting the author to define Hessian, covariant/exterior derivatives and Ricci curvature.
Quasi-Actions on Trees II: Finite Depth Bass-Serre Trees
This paper addresses questions of quasi-isometric rigidity and classification for fundamental groups of finite graphs of groups, under the assumption that the Bass-Serre tree of the graph of groups has finite depth. The main example of a finite depth graph of groups is one whose vertex and edge groups are coarse Poincare duality groups. The main theorem says that, under certain hypotheses, if $\mathcal{G}$ is a finite graph of coarse Poincare duality groups, then any finitely generated group quasi-isometric to the fundamental group of $\mathcal{G}$ is also the fundamental group of a finite graph of coarse Poincare duality groups, and any quasi-isometry between two such groups must coarsely p...
The Moment Maps in Diffeology
"This memoir presents a generalization of the moment maps to the category {Diffeology}. This construction applies to every smooth action of any diffeological group G preserving a closed 2-form w, defined on some diffeological space X. In particular, that reveals a universal construction, associated to the action of the whole group of automorphisms Diff (X, w). By considering directly the space of momenta of any diffeological group G, that is the space g* of left-invariant 1-forms on G, this construction avoids any reference to Lie algebra or any notion of vector fields, or does not involve any functional analysis. These constructions of the various moment maps are illustrated by many examples, some of them originals and others suggested by the mathematical literature."--Publisher's description.
Affine Insertion and Pieri Rules for the Affine Grassmannian
The authors study combinatorial aspects of the Schubert calculus of the affine Grassmannian ${\rm Gr}$ associated with $SL(n,\mathbb{C})$.Their main results are: Pieri rules for the Schubert bases of $H^*({\rm Gr})$ and $H_*({\rm Gr})$, which expresses the product of a special Schubert class and an arbitrary Schubert class in terms of Schubert classes. A new combinatorial definition for $k$-Schur functions, which represent the Schubert basis of $H_*({\rm Gr})$. A combinatorial interpretation of the pairing $H^*({\rm Gr})\times H_*({\rm Gr}) \rightarrow\mathbb Z$ induced by the cap product.
