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Molecular Biology of Mitochondrial Transport Systems
Mitochondrial transport systems are essential to mitochondrial function and therefore to energy homeostasis within the cell. The book contains studies utilizing the techniques of biochemistry, physiology, molecular biology and genetics to reveal the structure and function of mitochondrial transport systems. It is divided into the following six sections: - Proton Translocation: The Uncoupling Protein and the ATPase; - Carriers and Transporters; - Mitochondrial Ion Channels; Structure of the Outer Mitochondrial Membrane Channel, VDAC; - VDAC, Peripheral Kinases and Energy Utilization; - Mitochondrial Channels in Humans and Relationship to Disease.
Ion Channels
'Further establishes the reputation of the series...an invaluable resource.' -Trends in Pharmacological Sciences, from a review of Volume 3 Volume 4 explores such emergent topics as: three-dimensional conceptions of ion channel proteins based on the available structural and functional data; the structure, pharmacology, and regulation of the GABAA receptors; and the Ca2+-dependent K+ channels in adrenal chromatic cell membranes.
Chloride Channels
The amount of new information on the molecular biology of chloride channels has grown tremendously in recent years. This large amount of information gives some unique and, in some instances, surprising insights into the function and structure of chloride channels which are present in every cell. This volume contains a series of in-depth reviews of chloride channel physiology, biophysics, and molecular biology. The reviews cover chloride channels found in the plasma membrane as well as in organelles of both plant and animal cells.Key Features* Discusses CFTR, the cystic fibrosis transmembrane regulator, which is responsible for CF and the CIC-family of chloride channels responsible for myotonia congenita* In-depth reviews of chloride channel physiology, biophysics, and molecular biology* Reviews chloride channels found in the plasma membrane and in organelles of both plant and animal cells
Sphingolipids: Basic Science and Drug Development
Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids’ basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context.
Ion Channel Reconstitution
It is now over 30 years since the idea of ion-conducting pores burst on the elec trophysiological scene, 15 years since these were generalIy realized to be mem brane-spanning proteins, and 10 years since the first observations of single ion channels from higher organisms were made. During the past 5 years, several integral membrane channel proteins have been purified in a functionalIy competent state: the nicotinic acetylcholine receptor, the Na + channel, mitochondrial "VDAC," and a variety of porins. The stage is thus set to attack ion channels in the same ways that biochemists have been attacking enzymes for decades: isolation folIowed by functional analysis in as simple a system as possi...
Bioelectrochemistry III
This book contains aseries of review papers related to the lectures given at the Third Course on Bioelectrochemistry held at Erice in November 1988, in the framework of the International School of Biophysics. The topics covered by this course, "Charge Separation Across Biomembranes, " deal with the electrochemical aspects of some basic phenomena in biological systems, such as transport of ions, ATP synthesis, formation and maintenance of ionic and protonic gradients. In the first part of the course some preliminary lectures introduce the students to the most basic phenomena and technical aspects of membrane bioelectrochemistry. The remaining part of the course is devoted to the description o...
Bacterial and Eukaryotic Porins
This first book dedicated to the topic relates the known physiological functions of porins to their molecular structure and mechanism, as documented by various in vitro and in vivo methods, including the generation of null mutants in mice. For the first time, it brings together biophysical evidence with studies performed in a cellular context, presenting a unified picture of the fundamental importance of porins for cellular function. With 16 contributions by an interdisciplinary team of leading porin researchers, this reference is essential reading for every molecular or structural biologist with an interest in this essential protein family.
Bioactive Ceramides in Health and Disease
This book is about the various roles of bioactive ceramides and other sphingolipids in cellular biology. The enigmatic biophysical and biochemical properties of ceramides and their propensity to influence membranes whether as rafts or protein-permeable channels are heavily discussed. Metabolism of ceramides and their metabolites is also focused with ceramide synthase family of proteins being a target of extensive review. Ceramide 1-phosphate and other sphingolipids are also presented in cellular physiology and pathophysiology. Prokaryotic origins of mitochondria at the level of membranes and the occurrence of apoptosis in bacteria are presented. Many aspects of ceramide and sphingolipid biol...
Sediment Transport Mechanisms In Coastal Environments And Rivers - Euromech 310
These proceedings contain papers by some of the world's leading experts in the analytical and numerical modelling of sediment transport, its measurement on site and in the laboratory, river and coastal morphology, and similar issues. These topics are of fundamental importance in many areas (such as the silting or erosion of coasts and rivers, and the design of fluvial or coastal structures) and should consequently be of interest to a wide audience in engineering, geology and related disciplines.
Mitochondria
This book provides an update on the step-by-step "how to" methods for the study mitochondrial structure, function, and biogenesis contained in the successful first edition. As in the previous edition, the biochemical, cell biological, and genetic approaches are presented along with sample results, interpretations, and pitfalls from each method.
