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Principles of Molecular Medicine
The concept of molecular medicine dates back to Linus means that there are many new opportunities and challenges Pauling, who in the late 1940s and early 1950s generalized for clinical medicine. One of the effects of the completion of from the ideas that came from the study of the sickle cell the Human Genome Project is the increasing application of hemoglobin molecule. With the first cloning of human genes the fields of molecular biology and genetics to the und- about 1976, molecular genetics took the molecular perspec- standing and management of common diseases. Assimi- tive on disease to the level of DNA. The term molecular tion of the new developments since the first edition has been med...
Principles of Molecular Medicine
Within the framework of clinical internal medicine, they will gain critical knowledge of the many powerful molecular biology-based developments now so rapidly enhancing our understanding of the pathophysiology of disease, improving the feasibility and accuracy of diagnostic testing, and opening novel therapeutic avenues, including gene therapy. Readers will also gain a fuller understanding of the role played by genetic defects in a host of diseases, among them peripheral neuropathies, Alzheimer's disease, arrhythmias, leukemias and lymphomas, cystic fibrosis, hepatitis, HIV, autoimmune disorders, polycystic kidney disease, schizophrenia, affective disorders, alcoholism, Huntington's disease, and many more.
The Sassy One
The Marcelli Sisters of Pleasure Road series continues follows the three sisters as a secret threatens to rock their perfect world. Francesca Marcelli married at eighteen—right on schedule, according to her warm, colorful family, who have always said a beauty like Francesca need never worry about finding love. But a few years later, finding herself on her own with a wide-open future ahead of her, she pursues her educational passions—and a risky romance with playboy CEO Sam Reese. Delighted by Francesca’s interest in a no-strings relationship, Sam suddenly finds himself needing her outside the bedroom when a secret from his past lands on his doorstep. But Francesca soon has a secret of her own to tell—a bombshell that will force the diehard bachelor to show his true colors. Is marriage in Sam and Francesca’s future? Only if she can persuade him that home truly is where the heart finds happiness.
Pituitary Disorders throughout the Life Cycle
The pituitary gland is often referred to as the master gland, coordinating hormonal signals from the hypothalamus and peripheral circulation to maintain homeostasis in the body. Patients with pituitary dysfunction are faced with challenges unique to each stage of their life cycle. For example, the goals of management for a hypopituitary adolescent transitioning to adulthood would be to optimize growth and sexual development. In early adulthood, approaches that optimize of fertility in men and women can be a priority, and the management approach will be very different from that of older adults requiring sex hormone replacement. This case-based guide will provide practical clinical guidance on...
SEAFLOOR OBSERVATORIES
The oceans cover 70% of the terrestrial surface, and exert a pervasive influence on the Earth's environment but their nature is poorly recognized. Knowing the ocean's role deeply and understanding the complex, physical, biological, chemical and geological systems operating within it represent a major challenge to scientists today. Seafloor observatories offer scientists new opportunites to study multiple, interrelated natural phenomena over time scales ranging from seconds to decades, from episodic to global and long-term processes. Seafloor Observatories poses the important and apparently simple question, "How can continuous and reliable monitoring at the seafloor by means of Seafloor Obser...
Advances in Rapid Sex-Steroid Action
Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate multiple pathways leading to proliferation, survival, migration and invasiveness. The immediate challenge is the dissection of key events regulating the steroid response of target tissues to prevent progression and improve treatment of breast and prostate cancers.
International Day of Persons with Disabilities – Children’s Disabilities
The International Day of Persons with Disabilities (IDPD) serves to globally promote an understanding of disability issues and mobilize support for the dignity, rights, and well-being of persons with disabilities. The theme of the most recent United Nations Day was “transformative solutions for inclusive development: the role of innovation in fuelling an accessible and equitable world”. It is in this spirit that Frontiers in Public Health is launching a new article collection inspired by this UN day, with a specific focus on children with disabilities and how innovative public health solutions to support them can contribute to making the world a more equitable and prosperous world for all.
Androgens in Health and Disease
Authoritative researchers and clinicians review our latest understanding of andrology in both basic science and clinical medicine. Topics range from explaining the biology of androgens-from several different perspectives-to illuminating their role in the development and modulation of physiologic systems. Authors demonstrate in a number of cases that testosterone can be a useful adjunct to the treatment of a variety of disease states. Other chapters consider important topics such as androgens use in athletes, the potential of androgens to improve physical function and quality of life in older men, and androgens as potential male contraceptives.
Hormones, Brain and Behavior
Hormones, Brain and Behavior, Third Edition offers a state-of-the-art overview of hormonally-mediated behaviors, including an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. Entries have been carefully designed to provide a valuable source of information for students and researchers in neuroendocrinology and those working in related areas, such as biology, psychology, psychiatry, and neurology. This third edition has been substantially restructured to include both foundational information and recent developments in the field. Continuing the emphasis on interdisciplinary research and practical applications, the book includes articles a...
