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Marek’s Disease
Marek's disease virus (MDV) is a herpesvirus which causes a lymphoproliferative disorder of the domestic chicken worldwide. This serious economical problem caused by MDV was mostly solved by development of an effective vaccine against MDV. The development of live vaccines against the disease is remarkable as it has led to the first example of a commercially available vaccine against cancer as well as against diseases caused by herpesviruses.This volume gives an overview on many aspects of MDV research and summarizes recent advances in the field. The topics include the history, biology,and molecular biology of MDV, pathogenesis, vaccinal immunity, immune response, genetic resistance and development of recombinant polyvalent vaccines. It is hoped that this volume will make an important contribution towards the control of infectious diseases.
Marek’s Disease
Take a disease of complex pathology with inflammatory and neoplastic features, which affects lymphoid and neural tissues, belonging to a disease group which killed one chicken in five, and which defied efforts to understand and control it for !lOre than 50 years, and one can begin to appreciate the interest Marek's disease has received. Canpound these characteristics with the finding of the causal herpesvirus, its recog nition as the neoplasm first discovered to be so caused, and its pre vention by vaccination, and the special place of Marek's disease in veterinary medicine and comparative oncology becomes clear. This book sets out to provide an authoritative and corrprehensive account of knowledge of Marek's disease and its control. I hope that it will be of value to veterinary research workers, teachers and students who need information about the disease, to veterinarians, poultrymen and vaccine manufacturers who have to diagnose and control it, and to oncologists in other fields interested in comparative aspects. other reviews of the disease exist, of course, but this is the first multi authored book devoted to the subject.
Responsible Decision Making
“What should I do?,” “How should I deal with this?,” “How should I behave?,” “How should I act?” we ask ourselves daily. But, this is only the first part of the sentence, while the full sentence is “What should I do … to achieve such and such?”, for example to complete an assigned task, to do well before my boss or a client, to be pleased with myself, to carry out my plans, to make money in the stock market, to pass an exam, to complete an application, etc. These and similar questions that people ask, consciously or not, openly or not, are decisions. What skills must we master, especially when there is a need to make not only elementary decisions, but also decisions tha...
Marek's Disease
Marek’s disease is a form of cancer of poultry caused by an important herpesvirus (MDV). It continues to be a threat to poultry health and welfare and worldwide losses are estimated to be US$ 1 billion annually. Marek's Disease provides a timely review of the problems of Marek's disease with descriptions of the complex viral life cycle, how MDV targets different types of white blood cells, and details of the virus structure, its genes and proteins. The multiplicity of factors contributing to susceptibility is explored in detail Vaccination - the problems arising from current vaccination strategies and how these can be improved and made sustainable in future The lessons learned in the control of MD over the past 30 years, and how we can use MD as a model for other animal and human diseases is discussed
Monoamine Oxidases and their Inhibitors
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. In this volume, invited experts provide authoritative reviews on various aspects of Monoamine Oxidase and its Inhibitors. Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Managing Safety of Heterogeneous Systems
Managing safety of diverse systems requires decision-making under uncertainties and risks. Such systems are typically characterized by spatio-temporal heterogeneities, inter-dependencies, externalities, endogenous risks, discontinuities, irreversibility, practically irreducible uncertainties, and rare events with catastrophic consequences. Traditional scientific approaches rely on data from real observations and experiments; yet no sufficient observations exist for new problems, and experiments are usually impossible. Therefore, science-based support for addressing such new class of problems needs to replace the traditional “deterministic predictions” analysis by new methods and tools fo...
Protein Misfolding in Neurodegenerative Diseases
Current research suggests that neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and Creutzfeldt-Jacob may be linked to disorders in protein shape referred to as protein misfolding. Continued study in this area could lead to promising advances in future treatment of these diseases. This groundbreaking text describes the latest findings regarding protein misfolding in the context of it being a marker, and perhaps a cause, in neurodegenerative diseases. Comprehensive coverage includes the diverse biochemical targets/markers for each disease, the currently limited success of drug therapies, and the cutting-edge research that could lead to more promising treatments.
Gulliver in the Country of Lilliput
Noncovalent interactions are the bridge between ideal gas abstraction and the real world. For a long time, they were covered by two terms: van der Waals interactions and hydrogen bonding. Both experimental and quantum chemical studies have contributed to our understanding of the nature of these interactions. In the last decade, great progress has been made in identifying, quantifying, and visualizing noncovalent interactions. New types of interactions have been classified—their energetic and spatial properties have been tabulated. In the past, most studies were limited to analyzing the single strongest interaction in the molecular system under consideration, which is responsible for the mo...
Marek’s Disease
Marek's disease virus (MDV) is a herpesvirus which causes a lymphoproliferative disorder of the domestic chicken worldwide. This serious economical problem caused by MDV was mostly solved by development of an effective vaccine against MDV. The development of live vaccines against the disease is remarkable as it has led to the first example of a commercially available vaccine against cancer as well as against diseases caused by herpesviruses. This volume gives an overview on many aspects of MDV research and summarizes recent advances in the field. The topics include the history, biology,and molecular biology of MDV, pathogenesis, vaccinal immunity, immune response, genetic resistance and development of recombinant polyvalent vaccines. It is hoped that this volume will make an important contribution towards the control of infectious diseases.
