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Alzheimer's disease is the most common form of dementia in the elderly; 450,000 people in the UK and 4.5 million people in the USA suffer with this disease. This 3rd edition of Neurobiology of Alzheimer's Disease gives a comprehensive and readable introduction to the disease, from molecular pathology to clinical practice. The book is intended for readers new to the field, and it also covers an extensive range of themes for those with in-depth knowledge of Alzheimer's disease. It will therefore act either as an introduction to the whole field of neurodegeneration or it will help experienced researchers to access the latest research in specialist topics. Each chapter is written by eminent scie...
Completely rewritten and updated, this new edition is almost twice the size of its predecessor. Illustrated in colour throughout, and with contributions from the world's leading authorities, it is the definitive reference on the neuropathology of dementia. It gives practical guidance to pathologists, describes the contribution of neuroimaging to diagnosis, and surveys the clinical features of dementia. New material includes: Three entirely new chapters on neuroimaging, molecular diagnostics, and transgenic models. Two chapters on tauopathies under new authorship. A chapter under new authorship on synucleinopathies, which includes multiple system atrophy.
This key collection brings together a selection of papers commissioned and published by the Cardiff Centre for Ethics, Law & Society. It incorporates contributions from a group of international experts along with a selection of short opinion pieces written in response to specific ethical issues. The collection addresses issues arising in biomedical and medical ethics ranging from assisted reproductive technologies to the role of clinical ethics committees. It examines broader societal issues with particular emphasis on sustainability and the environment and also focuses on issues of human rights in current global contexts. The contributors collect responses to issues arising from high profile cases such as the legitimacy of war in Iraq to physician-related suicide. The volume will provide a valuable resource for practitioners and academics with an interest in ethics across a range of disciplines.
Within the current opiate crisis, this book provides a timely, comprehensive guide for psychological treatment with chronic pain patients. It is written for academic and practicing psychological professionals, in addition to graduate students, neuroscientists, and neuropsychologists. It provides an explanation of neurophysiological pain processing based the Dimensional Systems Model (DSM), a theory of higher cortical functions. Novel views on the roles of the basal ganglia, cerebellum, and cingulate cortex are presented here, while the applied Clinical Biopsychological Model (CBM) is used to explain psychological treatment with chronic pain patients. Three new areas of treatment focus are discussed in this book, including specific approaches to deal with influential negative emotional memories, interpersonal relationship stressors, and loss-related depression, all of which have been shown to influence chronic pain disorders. Detailed information on how to do assessment, conceptualization, and treatment is also provided. In total, the book offers a unique viewpoint unavailable in any other source.
In this exciting symposium, the editor brings to print important new information on AIDS and how HIV affects the brain. Each chapter focuses on one or more of the cell types that reside in or traffic through the central nervous system (CNS). Each of these cells is important to considerations of the pathogenesis of the CNS. Neurologists, AIDS physicians, and other professionals caring for AIDS patients will find that this “cell-based” view provides a unique perspective and that it will guide and stimulate future investigation of this clinically important and pathogenetically intriguing disorder. The editor also introduces some general considerations for therapeutic intervention of AIDS de...
The relevance of cognitive rehabilitation for people with dementia is becoming increasingly accepted by researchers and practitioners in the field. This special issue draws together examples of state-of-the-art research and systematic review by experts in this exciting and growing area. The contributors show how cognitive rehabilitation approaches can be applied, in different ways, to help optimise functioning and address specific difficulties across the full spectrum of severity. While the main focus is on the more commonly diagnosed forms of dementia, treatment possibilities for people with fronto-temporal dementia are also explored. Cognitive rehabilitation interventions need to be ground...
Schizophrenia is a unique project reflecting the contribution that Robin M. Murray has made to the field of psychiatry over the past 35 years, with a particular focus on the advances that have been made to the understanding and treatment of schizophrenia. International contributors have been brought together to pay tribute to Robin Murray’s work and explore the latest findings in the area. Sections cover: neurodevelopment neuroscience and pharmacology neuroimaging genetics cognition social psychiatry treatment. This book will be essential reading for psychiatrists, clinical psychologists, social and basic scientists whose work is related to major mental illness, as well as admirers of the work of Robin Murray.
Focusing mainly on case studies from Australia and the United States of America, this book considers how people with dementia represent themselves and are represented in ‘theatre of the real’ productions and care home interventions, assessing the extent to which the ‘right kind’ of dementia story is being affirmed or challenged. It argues that this type of story — one of tragedy, loss of personhood, biomedical deficit, and socio-economic ‘crisis — produces dementia and the people living with it, as much as biology does. It proposes two novel ideas. One is that the ‘gaze’ of theatre and performance offers a reframing of some of the behaviours and actions of people with demen...
Examines the post-mortem journeys of bodies, body-parts, organs, and brains in modern British medical research. This title is also available as Open Access.