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RNA Interference Technology
RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these genes. In the postgenomic era, the elucidation of the physiological function of genes has become the rate-limiting step in the quest to develop 'gene-based drugs' and RNAi could potentially play a pivotal role in the validation of such novel drugs. In this overview, the basic concepts and applications of RNAi biology are discussed. Leading experts from both academia and industry have contributed to this invaluable reference. The volume is forwarded by Andrew Fire, one of the winners of the 2006 Nobel Prize for the discovery of RNA Interference.
Cancer Research
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Health and Socio-economic Status Over the Life Course
Health in later life is shaped by behavior and policies over the life course and reflects the differences between the societies in which we are ageing. This multidisciplinary book answers questions from all life course phases and its interconnections from a European perspective based on the most recent SHARE data, such as: How is our health related to personality traits and influenced by our childhood conditions and careers? Which role does our social network play? Which impacts of the different health care and societal regimes can we trace at older ages? Which are the differences and similarities across European countries?
Systems Genetics
Whereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes. This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes. Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomyces cerevisiae and Drosophila melanogaster, as well as from human studies.
The Liver in Systemic Diseases
Based on the results of studies on autoimmunity, the endocrine system, nutrients, metal metabolism and intestinal bacterial flora, this volume thoroughly covers studies on functional correlation of the liver with the spleen, visceral fat, intestinal tract, and central nervous system. Including associations with dysbiosis, nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma, it offers comprehensive data on correlations of organs with the liver from basic and clinical viewpoints. The Liver in Systemic Diseases will especially be of interest to researchers, clinical residents and medical students with an interest in hepatology and gastroenterology. Furthermore, the book has interdisciplinary appeal and provides a foundation that will help physicians to consider clinical conditions of diseases from a broader perspective.
Advances in Virus Research
Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology. - Contributions from leading authorities - Informs and updates on all the latest developments in the field
Molecular Embryology
Most people have some interest in embryos; this probably results, in part, from their interest in understanding the biological origins of themselves and their offspring and, increasingly, concerns about how environmental change such as pollution might affect human development. Obviously, et- cal considerations preclude experimental studies of human embryos and, c- sequently, the developmental biologist has turned to other species to examine this process. Fortunately, the most significant conclusion to be drawn from the experimental embryology of the last two decades is the manner in which orthologous or closely related molecules are deployed to mediate similar - velopmental processes in both...
Oxidative Stress and Oxygen Radicals
This book is a printed edition of the Special Issue "Oxidative Stress and Oxygen Radicals" that was published in Biomolecules
Advances in Simulation and Digital Human Modeling
This book provides readers with a timely snapshot of modeling and simulation tools, including virtual and mixed-reality environment, for human factors research. It covers applications in healthcare and physical ergonomics, military and transportation systems, industrial monitoring, as well as economics and social sciences. Based on the AHFE 2021 International Conference on Human Factors and Simulation and the AHFE 2021 International Conference on Digital Human Modeling and Applied Optimization, held virtually on 25–29 July, 2021, from USA, the book offers a unique resource for modelling and simulation researchers seeking insights into human factors research and to human factors experts seeking reliable computational tools.
