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The Role of Physical and Biological Gut Barriers in Modulating Crosstalk between the Microbiota and the Immune System
The intestine has several means for maintaining immune homeostasis and for avoiding inflammation despite massive antigenic stimulation by food components and by commensal bacteria residing in the gut mucosa. These mechanisms include physical and biological barriers such as (i) the intestinal epithelial barrier (IEB); (ii) the gut vascular barrier (GVB) and (iii) the mucus layer. In particular, the mucus layer does not simply act as a diffusion barrier but has important dynamic functions that regulate the type of commensal bacteria residing in the inner mucus layer, enabling the passage of food and bacterial products into the gut tissue and systemic circulation. Importantly, the mucosal layer...
01 .Industrial Archaeology. European approach to recovery productive memory
[Italiano]: Il libro raccoglie i contributi di un lavoro interdisciplinare svolto durante un BIP (Blended Intensive Program) finanziato dalla comunità europea. Il tema è quello dei siti industriali dismessi e tutelati per interesse storico. Partendo da un confronto tra i diversi approcci basati sullo studio delle best practice e dei diversi metodi e strumenti di analisi, sono state definite alcune premesse per la rappresentazione del sito e lo sviluppo di ipotesi di trasformazione per il riuso dell'ex Corradini a S. Giovanni. Stimolare il dibattito culturale, confrontarsi con realtà culturali diverse, definire percorsi metodologici replicabili sono gli obiettivi principali di questo lavor...
Beyond Digital Representation
This book collects contributions which showcase the impact of new augmented reality (AR) and artificial intelligence (AI) technologies considered jointly in the fields of cultural heritage and innovative design. AR is an alternative path of analysis and communication if applied to several fields of research, in particular if related to space and artifacts in it. This happens because the neural network development strengthens the relationship between augmented reality and artificial intelligence, creating processes close to human thought in shorter times. In the last years, the AR/AI expansion and the future scenarios have raised a deep trans-disciplinary speculation. The disciplines of repre...
Immunologically Mediated Endocrine Diseases
Basic immunological principles and methods as they relate to cellular and subcellular processes of the endocrine system are important in understanding the underlying causes of endocrine disorders. Part of the Modern Endocrinology Series, this text covers a wide array of topics including pancreas development, immunogenetics, hypoparathyroidism, Graves' disease and vitiligo. The book is an integrated resource with a bench-to-bedside breadth that is useful to both basic scientists and healthcare professionals interested in endocrine autoimmune diseases.
Role of CD1- and MR1-restricted T cells in Immunity and Disease
CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice onl...
