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Available in English for the first time, this classic and influential book by the late Kohei Ohtsu presents real examples of ships in motion under irregular ocean waves, how to understand the characteristics of fluctuations of stochastic phenomena through spectral analysis methods and statistical modeling. It also explains how to realize prediction and optimal control based on time series models. In recent years, the need to improve safety and reduce environmental impact in ship operations has been increasing, and the statistical methods presented in this book will be increasingly needed in the future. In addition, the recent development of innovative AI technology and highspeed communicatio...
Bayesian variable selection has experienced substantial developments over the past 30 years with the proliferation of large data sets. Identifying relevant variables to include in a model allows simpler interpretation, avoids overfitting and multicollinearity, and can provide insights into the mechanisms underlying an observed phenomenon. Variable selection is especially important when the number of potential predictors is substantially larger than the sample size and sparsity can reasonably be assumed. The Handbook of Bayesian Variable Selection provides a comprehensive review of theoretical, methodological and computational aspects of Bayesian methods for variable selection. The topics cov...
This book constitutes the refereed proceedings of the 5th European Conference on Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics, EvoBIO 2007, held in Valencia, Spain, April 2007. Coverage brings together experts in computer science with experts in bioinformatics and the biological sciences. It presents contributions on fundamental and theoretical issues along with papers dealing with different applications areas.
Computational Anatomy (CA) is an emerging discipline aiming to understand anatomy by utilizing a comprehensive set of mathematical tools. CA focuses on providing precise statistical encodings of anatomy with direct application to a broad range of biological and medical settings. During the past two decades, there has been an ever-increasing pace in the development of neuroimaging techniques, delivering in vivo information on the anatomy and physiological signals of different human organs through a variety of imaging modalities such as MRI, x-ray, CT, and PET. These multi-modality medical images provide valuable data for accurate interpretation and estimation of various biological parameters ...
An observational study infers the effects caused by a treatment, policy, program, intervention, or exposure in a context in which randomized experimentation is unethical or impractical. One task in an observational study is to adjust for visible pretreatment differences between the treated and control groups. Multivariate matching and weighting are two modern forms of adjustment. This handbook provides a comprehensive survey of the most recent methods of adjustment by matching, weighting, machine learning and their combinations. Three additional chapters introduce the steps from association to causation that follow after adjustments are complete. When used alone, matching and weighting do not use outcome information, so they are part of the design of an observational study. When used in conjunction with models for the outcome, matching and weighting may enhance the robustness of model-based adjustments. The book is for researchers in medicine, economics, public health, psychology, epidemiology, public program evaluation, and statistics who examine evidence of the effects on human beings of treatments, policies or exposures.
Bayesian statistics is a dynamic and fast-growing area of statistical research and the Valencia International Meetings provide the main forum for discussion. These resulting proceedings form an up-to-date collection of research.
Bayesian Modeling in Bioinformatics discusses the development and application of Bayesian statistical methods for the analysis of high-throughput bioinformatics data arising from problems in molecular and structural biology and disease-related medical research, such as cancer. It presents a broad overview of statistical inference, clustering, and c
This volume presents a collection of peer-reviewed contributions arising from StartUp Research: a stimulating research experience in which twenty-eight early-career researchers collaborated with seven senior international professors in order to develop novel statistical methods for complex brain imaging data. During this meeting, which was held on June 25–27, 2017 in Siena (Italy), the research groups focused on recent multimodality imaging datasets measuring brain function and structure, and proposed a wide variety of methods for network analysis, spatial inference, graphical modeling, multiple testing, dynamic inference, data fusion, tensor factorization, object-oriented analysis and others. The results of their studies are gathered here, along with a final contribution by Michele Guindani and Marina Vannucci that opens new research directions in this field. The book offers a valuable resource for all researchers in Data Science and Neuroscience who are interested in the promising intersections of these two fundamental disciplines.
In today's healthcare landscape, there is a pressing need for quantitative methodologies that include the patients' perspective in any treatment decision. Handbook of Generalized Pairwise Comparisons: Methods for Patient-Centric Analysis provides a comprehensive overview of an innovative and powerful statistical methodology that generalizes the traditional Wilcoxon-Mann-Whitney test by extending it to any number of outcomes of any type and including thresholds of clinical relevance into a single, multidimensional evaluation. The book covers the statistical foundations of generalized pairwise comparisons (GPC), applications in various disease areas, implications for regulatory approvals and benefit-risk analyses, and considerations for patient-centricity in clinical research. With contributions from leading experts in the field, this book stands as an essential resource for a more holistic and patient-centric assessment of treatment effects.
The statistical study and development of analytic methodology for individualization of treatments is no longer in its infancy. Many methods of study design, estimation, and inference exist, and the tools available to the analyst are ever growing. This handbook introduces the foundations of modern statistical approaches to precision medicine, bridging key ideas to active lines of current research in precision medicine. The contributions in this handbook vary in their level of assumed statistical knowledge; all contributions are accessible to a wide readership of statisticians and computer scientists including graduate students and new researchers in the area. Many contributions, particularly ...