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Commercializing Nanomedicine
The authors of this book address all individuals approaching the study of nanomedicine for the first time ever, as well as those already profitably working in the field either as scientists, doctors, lawyers, or entrepreneurs. Teeming with accurate, up-to-date, and enjoyable content, the book describes some enlightening facts and figures pertaining
The Funnel: From the Skull Base to the Sacrum
Skull-base surgery is a minimally invasive endoscopic procedure, which involves the surgeon inserting instruments through the natural openings in the skull—the nose or mouth—or by making a small hole just above the eyebrow. This type of surgery requires a team of specialists, which may include ENT (ear, nose, and throat), maxillofacial and neurosurgeons, as well as radiologists. The craniovertebral junction (CVJ) has a unique anatomical bone and neurovascular structure, which not only separates the subaxial cervical spine but also provides a special cranial flexion, extension and axial rotation pattern. As such, a sound knowledge of the basic principles of spine instrumentation and the region’s kinematics are essential when it comes to strategic preoperative planning. Skull-base, craniovertebral junction, spine demolitive and reconstructive surgery, neuromodulation, bioengineering and transplantation are recent tools used to improve reconstruction, restoration and rehabilitation – three key words central to the core aim of the Neurorehabilitation and Reconstruction Committee of the WFNS, which is to promte mechanical morphological and functional restoration.
A Practical Manual for Cisternostomy
A Practical Manual for Cisternostomy: Essentials for Young Neurosurgeons is a first-of-its-kind book on this technique. This manual describes a common lifesaving procedure in head injury. Cisternostomy is a new concept for treating traumatic brain injuries. It has been evaluated by many surgeons around the world for more than a decade and it is expected to become an accepted method of treatment. This book will serve as a practical and comprehensive guide for young neurosurgeons and all practicing neurosurgeons. Salient Features The surgical technique and the physiology of cisternostomy represents a paradigm shift in neurosurgery. This book has elaborated on that along with various perspectives and exciting future avenues this will open. This book describes the history and philosophy of cisternostomy, anatomy of cisterns, indications of cisternostomy, procedure, nuances and complications, perspectives from surgeons around the world, literature evidence, and future perspectives on cisternostomy.
The Road from Nanomedicine to Precision Medicine
The enormous advances in nanomedicine and precision medicine in the past two decades necessitated this comprehensive reference, which can be relied upon by researchers, clinicians, pharmaceutical scientists, regulators, policymakers, and lawyers alike. This standalone, full-color resource broadly surveys innovative technologies and advances pertaining to nanomedicine and precision medicine. In addition, it addresses often-neglected yet crucial areas such as translational medicine, intellectual property law, ethics, policy, FDA regulatory issues, nano-nomenclature, and artificial nano-machines—all accomplished in a user-friendly, broad yet interconnected format. The book is essential reading for the novice and the expert alike in diverse fields such as medicine, law, pharmacy, genomics, biomedical sciences, ethics, and regulatory science. The book’s multidisciplinary approach will attract a global audience and serve as a valuable reference resource for industry, academia, and government.
Immune Aspects of Biopharmaceuticals and Nanomedicines
The enormous advances in the immunologic aspects of biotherapeutics and nanomedicines in the past two decades has necessitated an authoritative and comprehensive reference source that can be relied upon by immunologists, biomedical researchers, clinicians, pharmaceutical companies, regulators, venture capitalists, and policy makers alike. This text provides a thorough understanding of immunology, therapeutic potential, clinical applications, adverse reactions, and approaches to overcoming immunotoxicity of biotherapeutics and nanomedicines. It also tackles critical, yet often overlooked topics such as immune aspects of nano-bio interactions, current FDA regulatory guidances, complement activation-related pseudoallergy (CARPA), advances in nanovaccines, and immunogenicity testing of protein therapeutics.
Handbook of Clinical Nanomedicine
This handbook (55 chapters) provides a comprehensive roadmap of basic research in nanomedicine as well as clinical applications. However, unlike other texts in nanomedicine, it not only highlights current advances in diagnostics and therapeutics but also explores related issues like nomenclature, historical developments, regulatory aspects, nanosim
The Human Hypothalamus
The Human Hypothalamus: Neuroendocrine Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume summarizes the role of the hypothalamus in neuroendocrine disorders, identifying the mechanism of action, disorder etiology, and best practices for assessment and treatment. Disorders covered include pituitary hypothalamic disorders of development and growth, hypothalamic tumor related disorders, hypothalamic autoimmune disorders and infection, disorders of vasopressin, water and sodium homeostasis, eating disorders, and gonadotropic hormone regulation disorders. - Discusses the importance of the hypothalamus in human growth and development - Reviews hypothalamic related tumors, as well as pituitary, autoimmune, vasopressin and hormone regulation disorders - Includes metabolic and eating disorders - Identifies mechanisms of disease action and etiology - Provides best practice information for assessment and treatment
Cervical Myelopathy, An Issue of Neurosurgery Clinics of North America
This issue of Neurosurgery Clinics, edited by Dr. Michael G. Fehlings and Dr. Junichi Mizuno, focuses on Cervical Myelopathy. Topics include, but are not limited to, Epidemiology and overview of the clinical spectrum of degenerative cervical myelopathy; Pathobiology of degenerative cervical myelopathy; Natural history of degenerative cervical myelopathy; Imaging evaluation of degenerative cervical myelopathy: current state of the art and future directions; Pathophysiology of CPPD and OYL(OLF); Radiological evaluation of OPLL with dural ossification; Relationship of OALL, OPLL and OYL (OLF); Importance of sagittal alignment of the cervical spine in the management of degenerative cervical myel...
A Light in the Dark
THE FIRST BOOK BY A CONFIRMED SURVIVOR OF TED BUNDY, AND THE ONLY MEMOIR TO CHALLENGE THE POPULAR NARRATIVE OF BUNDY AS A HANDSOME KILLER WHO CHARMED HIS VICTIMS INTO TRUSTING HIM In January 1978, I slept in my bed at the Chi Omega sorority house at Florida State University as Ted Bundy stalked nearby. He grabbed an oak log from a stack of firewood, slipped through a back door with a broken padlock, and headed upstairs.He began twisting doorknobs. Room 9 was open, and he quietly and quickly killed one of my sleeping sorority sisters. Across the hall, he found another unlocked door and murdered again. Then, he turned the knob to my bedroom and found it was open. I remember the attack vividly....
New Trends in Craniovertebral Junction Surgery
This issue of Acta Neurochirururgica presents the latest surgical and experimental approaches to the craniovertebral junction (CVJ). It discusses anterior midline (transoral transnasal), posterior (CVJ craniectomy laminectomy, laminotomy, instrumentation and fusion), posterolateral (far lateral) and anterolateral (extreme lateral) approaches using state-of-the-art supporting tools. It especially highlights open surgery, microsurgical techniques, neuronavigation, the O-arm system, intraoperative MR, neuromonitoring and endoscopy. Endoscopy represents a useful complement to the standard microsurgical approach to the anterior CVJ: it can be used transnasally, transorally and transcervically; an...
