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Metal Ions and Neurodegenerative Disorders
Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation.Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer's, Wilson...
Isotope Research in Zooarchaeology
New techniques for understanding animal and human interactions in the past Through case studies of faunal remains from Roman Britain, prehistoric Southeast Asia, ancient African pastoral cultures, and beyond, this volume illustrates some of the ways stable isotope analysis of ancient animals can address key questions in human prehistory. Contributors use a diverse set of isotopic techniques to investigate social and biological topics, including human paleodiets and foodways, hunting and procurement strategies, exchange patterns, animal husbandry and the genetic consequences of domestication, and short- and long-term environmental change. They demonstrate how different isotopes can be used alone or in conjunction to address questions of animal diet, movement, ecology, and management. Studies also examine how sampling strategies, statistical techniques, and regional and temporal considerations can influence isotopic results and interpretations. By applying these new methods in concert with traditional zooarchaeological analyses, archaeologists can explore questions about human ecology and environmental archaeology that were previously deemed inaccessible.
Africa
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Metal Ions And Neurodengenerative Disorders
Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation.Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer's, Wilson...
Principles and Practice of Geriatric Psychiatry
The renowned Principles and Practice of Geriatric Psychiatry, now in its third edition, addresses the social and biological concepts of geriatric mental health from an international perspective. Featuring contributions by distinguished authors from around the world, the book offers a distinctive angle on issues in this continually developing discipline. Principles and Practice of Geriatric Psychiatry provides a comprehensive review of: geriatric psychiatry spanning both psychiatric and non-psychiatric disorders scientific advances in service development specific clinical dilemmas New chapters on: genetics of aging somatoform disorders epidemiology of substance abuse somatoform disorders care...
The Genealogy of a Gene
The history of the CCR5 gene as a lens through which to view such issues as intellectual property, Big Pharma, personalized medicine, and race and genomics. In The Genealogy of a Gene, Myles Jackson uses the story of the CCR5 gene to investigate the interrelationships among science, technology, and society. Mapping the varied “genealogy” of CCR5—intellectual property, natural selection, Big and Small Pharma, human diversity studies, personalized medicine, ancestry studies, and race and genomics—Jackson links a myriad of diverse topics. The history of CCR5 from the 1990s to the present offers a vivid illustration of how intellectual property law has changed the conduct and content of ...
