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Magnetic Resonance of Myelin, Myelination, and Myelin Disorders
Magnetic resonance imaging (MRI) is now considered the imaging modality of choice for the majority of disorders affecting the central nervous system. This is particularly true for gray and white matter disorders, thanks to the superb soft tis sue contrast in MRI which allows gray matter, unmyelinated, and myelinated white matter to be distinguished and their respective disorders identified. The pre sent book is devoted to the disorders of myelin and myelination. A growing amount of detailed in vivo information about myelin, myelination, and myelin dis orders has been derived both from MRI and from MR spectroscopy (MRS). This prompted us to review the clinical, laboratory, biochemical, and pa...
Magnetic Resonance of Myelination and Myelin Disorders
Our thanks go to our colleagues at the VU Univer- Preface to the Third Edition sity Medical Center and to those in other hospitals Reading through the prefaces of the two previous edi- who referred their patients to us. We are indebted to tions,we can say that much of what was said there still all colleagues who allowed us to use their MR images, holds. At the same time,however,much has changed. published or unpublished,making it possible for us to There has been immense progress in the technical present illustrations of nearly all known white matter possibilities of magnetic resonance and in the know- disorders. Two colleagues were particularly helpful ledge of genetic defects, biochemical ...
MRI of the Brain, Head, Neck and Spine
With the growing number of MR installations, clinicians and radiologist are being confronted more and more with visual information they do not feel as confident with as with the more 'mono-form' infor mation of conventional radiographs, CT and US. The freedom of parameter choice ofthe MR operator allows the same object to be depicted in various ways and the contrast in the images to be changed and inverted at will. For those not experienced in interpreting MR images, this may cause confusion and uncertainty about their diagnostic content. This will sometimes lead to an unnecessary retreat to other diagnostic modalities. The purpose of this book is to help close the gap between MR operators a...
Magnetic Resonance of Myelin, Myelination and Myelin Disorders
Clearly structured, each chapter describes: * clinical features and laboratory investigations * pathology * pathogenetic considerations * therapy * case presentation * MRI and spectroscopy of a specific myelin disorder Completely updated and expanded by 20 chapters to include the latest information on: - inborn errors of metabolism and neurodegenerative disorders - the role of subcellular structures - enzyme biochemistry - the pathophysiological mechanisms of posthypoxic-ischemic cerebral damage - inflammatory and infectious disorders Plus: Greater coverage of the genetic and pathophysiological mechanisms underlying white matter disorders. Finally: 250 high-quality illustrations depict rare disorders which previously were only described.
Cryopreservation of Plant Germplasm I
The germ plasm of numerous plant species, especially those of forest trees, some agricultural crops, and medicinal plants, is endangered and threatened with extinction. This depletion of germplasm pools and the shrinkage of naturally occurring genetic resources have caused international concern. Conventionally, the germplasm of plants is conserved through seeds, tubers, roots, corms, rhizomes, bulbs, cuttings, etc. However, the germ plasm of a number of trees and plantation crops (such as coconut, cocao, coffee, oil palm, rubber, mango, horse chestnut, etc. ) cannot be preserved since their seed are short-lived (recalcitrant). Likewise, germplasm of vegetatively propagated crops (such as pot...
Physician’s Guide to the Laboratory Diagnosis of Metabolic Diseases
This second edition of The Physician's Guide provides paediatricians and other physicians with a unique aid to help them select the correct diagnosis from a bewildering array of complex clinical and laboratory data. Delay and mistakes in the diagnosis of inherited metabolic diseases may have devastating consequences. The guide, which includes a CD-ROM, describes 298 disorders which have been grouped into 35 chapters according to the type of condition. Within each group of disorders, chapters provide tables of pertinent clinical findings as well as reference and pathological values for crucial metabolites. Relevant metabolic pathways and diagnostic flow charts are included. There are three indices to make the book as user-friendly as possible.
Magnetic Resonance Neuroimaging
Magnetic Resonance Neuroimaging is a comprehensive volume that focuses on the newest fields of MRI from functional and metabolic mapping to the latest applications of neuro-interventional techniques. Each chapter offers critical discussions regarding available methods and the most recent advances in neuroimaging, including such topics as the use of diffusion and perfusion MRI in the early detection of stroke, the revolutionary advent of high-speed MRI for non-invasively mapping cortical responses to task activation paradigms, and the principles and applications of contrast agents. The chapters also discuss how these new advances are applied to problems in patients ranging in age from the newborn to the elderly, as well as disease states ranging from metabolic encephalopathy to cardiovascular disorders and stroke. Magnetic Resonance Neuroimaging will be a valuable text/reference for residents, research fellows, and clinicians in radiology, neuroradiology, and magnetic resonance imaging.
Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases
This book, combining and updating two previous editions, is a unique source of information on the diagnosis, treatment, and follow-up of metabolic diseases. The clinical and laboratory data characteristic of rare metabolic conditions can be bewildering for both clinicians and laboratory personnel. Reference laboratory data are scattered, and clinical descriptions may be obscure. The Physician’s Guide documents the features of more than five hundred conditions, grouped according to type of disorder, organ system affected (e.g. liver, kidney, etc) or phenotype (e.g. neurological, hepatic, etc). Relevant clinical findings are provided and pathological values for diagnostic metabolites highlighted. Guidance on appropriate biochemical genetic testing is provided. Established experimental therapeutic protocols are described, with recommendations on follow-up and monitoring. The authors are acknowledged experts, and the book will be a valuable desk reference for all who deal with inherited metabolic diseases.
