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PEGylated Protein Drugs: Basic Science and Clinical Applications
PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.
The Spirit of Faith
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Base Closure
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Critical Incident Management
Most businesses are aware of the danger posed by malicious network intruders and other internal and external security threats. Unfortunately, in many cases the actions they have taken to secure people, information and infrastructure from outside attacks are inefficient or incomplete. Responding to security threats and incidents requires a competent
Freedom of Association for Chinese Workers
Contains testimony and prepared statements by Amy Hall and Phil Fishman.
Fatal or Fragile
That’s what happens to all who forget God ... They hang their life from one thin thread, they hitch their fate to a spider web. Job 8:13-14, The Message Satan’s diabolical web is designed to manipulate, control, and ultimately kill you! In a strategic display of grace and beauty, yet tensed with violence and catastrophe, His web is not passive. His venom is radical. Is there a way to neutralize this venom? Is there a way out of this fatal trap? Learn how satan’s intricate death trap can be swept away to nothingness.
