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PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.
The author makes the case for direct marketing progressively dominating all marketing communications, not in terms of execution, but in attitude of mind and overall strategic viewpoint.
A UNIQUE TEXT THAT BRIDGES THE GAP BETWEEN BASIC AND CLINICAL ANATOMY Filled with 50 cases that consider 130 possible diagnoses, and more than 250 illustrations, this concise, highly accessible book is a must for medical students and professionals preparing for their courses, boards, and practice. With each chapter, you will gain insight into the fundamentals of human anatomy and--just as importantly--its relevance to actual clinical practice. Clinical Anatomy features an intuitive body region organization, which is consistent with the common instructional approach of medical gross anatomy courses. No other guide offers you the opportunity to interact with clinical conditions on a level that...
This series was established to create comprehensive treatises on specialized topics in developmental biology. Such volumes are especially vital in develop mental biology, since it is a very diverse field that receives contributions from a wide variety of disciplines. This series is a meeting-ground for the various practitioners of this science, facilitating an integration of heterogeneous infor mation on. specific topics. Each volume is intended to provide the conceptual basis for a comprehen sive understanding of its topic as well as an analysis of the key experiments upon which that understanding is based. The specialist in any aspect of devel opmental biology should understand the experimental background of the field and be able to place that body of information in context to ascertain where additional research would be fruitful. At that point, the creative process takes over, and new experiments are designed. This series is intended to be a vital link in that ongoing process of learning and discovery. If it facilitates schol arship, it will serve an important function.
Maida Springer was an active participant in shaping a history that involved powerful movements for social, political and economic equality and justice for workers women, and African Americans. Maida Springer is the first full-length biography to document and analyze the central role played by Springer in international affairs, particularly in the formation of AFL-CIO's African policy during the Cold War and African independence movements. Richards explores the ways in which pan-Africanism, racism, sexism and anti-Communism affected Springer's political development, her labor activism, and her relationship with labor leaders in the AFL-CIO, the International Confederation of Free Trade Unions...
Sustainable Regeneration of Former Military Sites is the first book to analyze a profound land use change happening all over the world: the search for sustainable futures for property formerly dedicated to national defense now becoming redundant, disposed of and redeveloped. The new military necessity for rapid flexible response requires quite different physical resources from the massive fixed positions of the Cold War, with huge tracts of land and buildings looking for new uses. The transition from military to civilian life for these complex, contaminated, isolated, heritage laden and often contested sites in locations ranging from urban to remote is far from easy. There is very little sys...
The Greatest need of every believer is expressed in the prayers found in Ephesians 1:17-23 & Ephesians 3:14-21. Understand and experience the life-changing power in these prayers. EVERY breakthrough in faith comes from a breakthrough in revelation. EVERY breakthrough in receiving the blessings of God comes from a breakthrough in the spirit of wisdom and revelation. EVERY advance in fulfilling the call of God in our lives comes from a breakthrough in the spirit of wisdom and revelation. The tremendous power that is available to every believer is accessed through the supernatural revelation of who we are and what we have in Christ. THIS CHANGES EVERYTHING!
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