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Cancer imposes daunting effects on the nervous system Brain cancer is one of the most devastating diagnoses a physician can deliver. Cancer of the nervous system can take many different forms. Treatment is specific to the type of malignancy, its location in the nervous system and, increasingly, its molecular characteristics. The challenges manifest further when management choices need to be made, and multidisciplinary approaches are required. Additional complexities arise in children, where the developing neurological system requires more sensitive treatment. Neuro-oncology unmasks the complexities to provide a straightforward guide to cancers of the nervous system. Following a general appro...
The credit crunch is affecting every investor and every consumer, every industry and every government program, yet few people truly understand how it happened. Subprime mortgages have been center stage, but behind the scenes a conspiracy of greed among bankers, investors, rating agencies and regulators has imperiled everyone's financial future. We need to know what went wrong and how to change the practices that led to this calamity. Bloomberg columnist Mark Gilbert shows how Wall Street's tolerance for extremes made the global credit crunch both foreseeable and inevitable. He offers a blow-by-blow account of what went wrong and what lessons need to be learned from the crisis. Gilbert's argument—that everyone with skin in the money game had a vested interest in pretending that nothing could go awry—is a well-defended, compelling indictment of the financial community. Gilbert is able to make complex financial events easy to understand. His outlook is truly global: this financial crisis respects no geographical boundaries, and Gilbert draws on anecdotes and examples from around the world to make his case.
Cerebral gliomas account for 45% of all primary central nervous system (CNS) tumors. The median survival after the initial diagnosis of glioblastoma (GBM) is only 15 months, and less than 10% of patients survive three years post-diagnosis. Surgical treatment followed by adjuvant therapies such as radiotherapy and chemotherapy represents the classical strategy in glioma management. The revised WHO 2016 classification now distinguishes the oligodendrogliomas with 1p19q codeletion and IDH mutation from the astrocytomas with or without IDH mutations, thereby creating homogenous and pathologically distinct subgroups. While the status of gene expression and mutations define components of GBM subtypes, it was also found that response to therapies was different for each subtype, suggesting that personalized treatment based on genomic alterations could lead to a more favorable outcome for this disease.
CANCER CONSULT New edition covering the specialties of hematology, oncology and cellular therapy, now in two volumes Cancer Consult: Expertise in Clinical Practice, Volume 1: Solid Tumors & Supportive Care, Second Edition includes hundreds of answers to practice-based questions covering the new principles of diagnosis, classification, staging, treatment, and outcomes in the rapidly advancing field of cancer. This textbook series also provides expert guidance in the areas of cancer-related uncertainties and controversies, including experience-based discussions. The book’s smaller size allows for easy access during medical rounds. This volume also includes: Up-to-date, clinically relevant in...
An ideal study companion for the landmark neurology text Merritt’s Neurology, Merritt’s Neurology Review provides hundreds of case-based questions and answers to help you prepare for exams and keep you up to date in the field. Edited by Drs. Andrew Bauerschmidt, Jon Rosenberg, James M. Noble, Stephan A. Mayer, and Elan D. Louis, this all-new review tool has been compiled by Merritt’s Neurology authors and is designed to be used effectively both in print and online.
Ode of the Knight is a tale about a young man who suffers the loss of his father. Unable to cope with the trauma, he quickly realizes that he, the eldest son, can not fulfill his father's shoes. Embarking on a path of denial, his world and his loving family begin to fall apart before his very eyes. His shame in his failure plunges him into the depths of hell. Incapable of improving his situation he rejects life and everything of value. Soon the fifteen year old finds himself in predicaments far beyond his grasp of reality. He lives in his own world by his own rules. The child's obsession for punishment and self abasement is paramount. A series of poor decisions resulted in an involuntary mee...
Remote working is the new reality, and transactional work – provided by freelancers, contract employees or consultants – has increased exponentially. It is forecast that as much as half the labor force will be working independently and virtually by 2020.Most organizations are still grappling with how to effectively manage their virtual staff and how to effectively support and motivate them – an increasingly urgent task as more Millennials join the workforce, bringing changed attitudes to work satisfaction. This book, the fruit of the author’s three decades of experience planning and implementing remote working environments, provides expert guidance for anyone planning a shift to remo...
Written by international authorities, this book is aimed at clinicians dealing with male patients rendered infertile by cancer therapy.
"Neuro-oncology is an embryonic field of cancer research with a number of clinical trials in progress. However, the prognosis on neuro-oncologic patients has remained poor. Moreover, several small scale phase I/II trials performed have proved to be inconcl"