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Human iPSC-derived Disease Models for Drug Discovery
Since their development a decade ago, human induced pluripotent stem cells (iPSC) have revolutionized the study of human disease, given rise to regenerative medicine technologies, and provided exceptional opportunities for pharmacologic research. These cells provide an essentially unlimited supply of cell types that are difficult to obtain from patients, such as neurons or cardiomyocytes, or are difficult to maintain in primary cell culture. iPSC can be obtained from patients afflicted with a particular disease but, in combination with recently developed gene editing techniques, can also be modified to generate disease models. Moreover, the new techniques of 3 Dimensional printing and materials science facilitate the generation of organoids that can mirror organs under disease conditions. These properties make iPSC powerful tools to study how diseases develop and how they may be treated. In addition, iPSC can also be used to treat conditions in which the target cell population has been lost and such regenerative approaches hold great promise for currently untreatable diseases, including cardiac failure or photoreceptor degenerations.
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Psychology and Gender
Gender, an important concept in psychology, is brought into sharp focus in the 1984 Nebraska Symposium on Motivation, which presents important new findings in eight papers, four dealing with sex differences and four with gender as a variable.ø The papers on sex differences with Ann Anastasi's "Reciprocal Relations between Cognitive and Affective Development?with Implications for Sex Differences," in which the author relates aptitudes aboutøthe sex appropriateness of behaviors to attitudes and task performance. The effects of prenatal sex hormones on gender identity and gender-roleøbehavior are the subject of the next paper, "Gender Differences: A Biosocial Perspective" by Anke A. Ehrhardt...
Multi-Method Social Science
This book provides the first systematic guide to designing multi-method research, considering a wide range of statistical and qualitative tools.
Mobilizing Force
"Considering a wide range of democratic states, explores the interrelationships among perceived security threats, the militarization of security policy, and democratic accountability"--
