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Single-Cell OMICs Analyses in Cardiovascular Diseases
Single-cell OMICs analyses have recently become one of the most promising tools to probe biology at the cellular level, in large part due to its ability to address issues beyond the bulk analysis – a window into cellular heterogeneity. The ability to profile transcriptomic, epigenomic, proteomics, and metabolomics at the single cell level including more recently the spatial information has enhanced our ability to understand interactions between biomolecules in different contexts leading to the discovery of specific cellular subpopulations as well as biological mechanisms underlying pathologies which may be amenable to therapeutic interventions. The scale and availability of a variety of technologies to measure intricate molecular details have provided an impetus to research in many disease areas, including cardiovascular medicine.
Well-Being
The nature of well-being is one of the most enduring and elusive subjects of human inquiry. Well-Being draws upon the latest scientific research to transform our understanding of this ancient question. With contributions from leading authorities in psychology, social psychology, and neuroscience, this volume presents the definitive account of current scientific efforts to understand human pleasure and pain, contentment and despair. The distinguished contributors to this volume combine a rigorous analysis of human sensations, emotions, and moods with a broad assessment of the many factors, from heredity to nationality, that bear on our well-being. Using the tools of experimental science, the ...
Sin and Grace
Originally published in Dutch in the USA in 1923 and titled Van Zonde en Genade, book argues against the concept of a common grace of God to the reprobate that was first introduced into theological circles by Dr. Abraham Kuyper of the Netherlands. Authors show the theory of common grace to be unbiblical and contrary to the Reformed continental creeds. The authors supply a brief history of the importance of particular grace in Reformed theology, land ay out their analysis of sin and grace using an "organic" approach, often quoting from Kuyper's work De Gemeene Gratie. They answer pro-common grace arguments of Rev. Henry Wierenga of the Christian Reformed Church and of Dr. Valentine Hepp of the Free University of Amsterdam. They also exegete key Bible passages that pro-common grace men were fond of quoting. This book is of historical importance in revealing the controversies of the 1920s, which resulted, after the pubication of the book, in the deposition of both authors from the Christian Reformed Church and their helping to found the Protestant Reformed Churches, which stood squarely against common grace and for a particular grace of God in the salvation of the elect.
Perspectives on Anxiety, Panic, and Fear
Modern conceptualization of the multidimensional nature of anxiety, panic, and fear are examined from a variety of perspectives, including theories of emotion and cognition, neuropsychology, and conditioning.øCarroll E. Izard and Eric A. Youngstrom open with a review of Differential Emotions Theory. In the second chapter, Jeffrey A. Gray and Neil McNaughton summarize and update Gray's neuropsychological theory of anxiety. Susan Mineka and Richard Zinbarg consider what modern conditioning theory contributes to the understanding of emotion, and Richard J. McNally offers an overview of the application of experimental cognitive paradigms to fear, panic, and anxiety.øThe volume concludes with a...
Generalized Anxiety Disorder
In the last decade, tremendous progress has been made in understanding and addressing generalized anxiety disorder (GAD), a prevalent yet long-neglected syndrome associated with substantial functional impairment and reduced life satisfaction. This comprehensive, empirically based volume brings together leading authorities to review the breadth of current knowledge on the phenomenology, etiology, pathological mechanisms, diagnosis, and treatment of GAD. Provided are psychological and neurobiological models of the disorder that combine cutting-edge research and clinical expertise. Assessment strategies are detailed and promising intervention approaches described in depth, including cognitive-behavioral, interpersonal, psychodynamic, and pharmacological therapies. Also covered are special issues in the treatment of GAD in children, adolescents, and older adults.
Physics Briefs
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