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'This monograph will appeal to clinical microbiologists, and virologists involved in the care of transplant recipients and AIDS patients, as it provides the scientific basis of antiviral drug activity, molecular diagnosis and also of possible immunopathogenic mechanisms of CMV disease and CMV-related graft rejection.... it is highly recommended.'
Cytomegalovirus (CMV) infection causes severe diseases in immunocompromised patients. CMV-related morbidity is frequently linked to aberrant immune responses occurring locally within the respective tissues including immune-privileged sites such as the retina. There is growing evidence that CMV-related pathomechanisms differ profoundly as a function of cell type and differentiation state of the host cell. This book provides important new insights into CMV-related immunopathology, discusses molecular mechanisms involved in HCMV-mediated tissue injury, CMV latency and reactivation, and presents novel ideas and concepts to develop alternative antiviral drugs. As an important focus, the role of C...
Successful biofunctional surface engineering will determine the future of medical devices such as orthopedic implants, stents, catheters, vaccine scaffolds, wound dressings, and extracorporeal circulation devices. Moreover, the biosensor and diagnostic chip technology will evolve rapidly due to the growing medical need for personalized medicine. A
The contributions in this volume combine fundamental questions of common sense geography with case studies of ancient geographical texts. The book bridges synchronic cognitive linguistic and cognitive psychological approaches to the ancient texts with a diachronic perspective. The mental modeling of common sense geography is a fruitful theoretical approach, to gain deeper insights in universal and cultural-specific mnemonic representational systems on the one hand, and to enhance our understanding of ancient geography on the other. (Series: Ancient Culture and History / Antike Kultur und Geschichte - Vol. 16)
Takes the recent wave of German autobiographical writing on illness and disability seriously as literature, demonstrating the value of a literary disability studies approach.