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Official Gazette
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Toxicity and Drug Testing
Modern drug design and testing involves experimental in vivo and in vitro measurement of the drug candidate's ADMET (adsorption, distribution, metabolism, elimination and toxicity) properties in the early stages of drug discovery. Only a small percentage of the proposed drug candidates receive government approval and reach the market place. Unfavorable pharmacokinetic properties, poor bioavailability and efficacy, low solubility, adverse side effects and toxicity concerns account for many of the drug failures encountered in the pharmaceutical industry. Authors from several countries have contributed chapters detailing regulatory policies, pharmaceutical concerns and clinical practices in their respective countries with the expectation that the open exchange of scientific results and ideas presented in this book will lead to improved pharmaceutical products.
Making Mexican Chicago
An exploration of how the Windy City became a postwar Latinx metropolis in the face of white resistance. Though Chicago is often popularly defined by its Polish, Black, and Irish populations, Cook County is home to the third-largest Mexican-American population in the United States. The story of Mexican immigration and integration into the city is one of complex political struggles, deeply entwined with issues of housing and neighborhood control. In Making Mexican Chicago, Mike Amezcua explores how the Windy City became a Latinx metropolis in the second half of the twentieth century. In the decades after World War II, working-class Chicago neighborhoods like Pilsen and Little Village became s...
Border Correspondent
This first major collection of former Los Angeles Times reporter and columnist Ruben Salazar's writings, is a testament to his pioneering role in the Mexican American community, in journalism, and in the evolution of race relations in the U.S. Taken together, the articles serve as a documentary history of the Chicano Movement of the 1960s and of the changing perspective of the nation as a whole. Since his tragic death while covering the massive Chicano antiwar moratorium in Los Angeles on August 29, 1970, Ruben Salazar has become a legend in the Chicano community. As a reporter and later as a columnist for the Los Angeles Times, Salazar was the first journalist of Mexican American background...
Carbohydrate Chemistry
In this volume, glycochemistry and glycobiology have been combined to demonstrate the contribution of organic chemistry, modern analytics, biological and biochemical expertise to the increasingly important field of glycomics. A polysaccharide immunomodulator with therapeutic implications, carbohydrate vaccines, new findings emphasizing the influence of carbohydrate decoration on the regulation of inflammatory response and new therapeutic approaches in the treatment of acute and chronic inflammatory diseases, recent progress on glycoengineering based on a glycosylation strategy to optimize protein drugs, congenital disorders of glycosylation, and key aspects of the glycosylation changes assoc...
Foundations on Natural and Artificial Computation
The two volumes, LNCS 6686 resp. LNCS 6687, constitute the refereed proceedings of the 4th International Work-Conference on the Interplay between Natural and Artificial Computation, IWINAC 2011, held in La Palma, Canary Islands, Spain, in May/June 2011. The 108 revised full papers presented in LNCS 6686 resp. LNCS 6687 were carefully reviewed and selected from numerous submissions. The first part, LNCS 6686, entitled "Foundations on Natural and Artificial Computation", includes all the contributions mainly related to the methodological, conceptual, formal, and experimental developments in the fields of neurophysiology and cognitive science. The second part, LNCS 6687, entitled "New Challenges on Bioinspired Applications", contains the papers related to bioinspired programming strategies and all the contributions related to the computational solutions to engineering problems in different application domains, specially Health applications, including the CYTED ``Artificial and Natural Computation for Health'' (CANS) research network papers.
