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Inhibition of Tumor Induction and Development
The primary purpose of this book is to bring to the attention of members of the medical and scientific communities, as well as to other interested persons, a new and expanding area of investigation that features the use of chemicals for the prevention of tumor induction and development. This novel use of chemical compounds has succeeded in producing a remarkable series of discoveries in recent years. Some of these are beginning to be evaluated in the field of clinical oncology in a manner that has potentially enormous public health implications. It is anticipated, therefore, that increasing amounts of time, energy, and financial resources will be devoted to the further development and expans...
Diet and Cancer
The American Institute for Cancer Research (AICR) sponsored its third annual confer ence on nutrition and cancer. The theme was "Diet and Cancer: Markers, Prevention, and Treatment. " The conference was held October 29-30, 1992 at the Ritz Carlton Hotel in McLean, Virginia. This proceedings contains chapters from the platform presentations and abstracts from the poster presentations. Several chapters address each of four session topics: Retinoids as Differentiation Agents in Cancer Therapy, Biological Markers of Cancer Risk, Chemoprevention of Cancer by Non-Nutrients in Foods, and Nutritional Problems and Support in the Treatment of Cancer. The first three chapters discuss in detail differen...
Recovery from Brain Damage
The present volume is based upon the invited review lectures delivered to the European Brain and Behaviour Society's Workshop on Recovery of Function Following Brain Damage held at Goldsmiths' College, University of London, in April 1991. Coming exactly ten years after the Society's ftrst meeting on this subject, held at Erasmus University, Rotterdam, a major objective of the Workshop was to review progress in the intervening years. This task was begun by Professor D. G. Stein in his opening presentation. Looking ahead to possible developments in recovery research in the next decade was the subject of Professor B. Kolb's closing lecture. The intervening presentations reviewed progress made in speciftc areas of recovery research. In addition to reviewing progress over the last decade we sought to achieve an additional objective in the way that the invited review lectures were organised. This was to bring together those doing basic research, usually animal research, and those whose of the lectures were "paired", research interests are more clinically orientated. Thus some one concentrating on the results of animal studies and one on clinical research findings.
Pancreatic Islet Cell Regeneration and Growth
Aaron I. Vinik, M.D., Ph.D. I IEastem Virginia Medical School The Diabetes Institutes Norfolk, Virginia 23510 This symposium, held in June 1991, was a gathering of international scientists to exchange their views on current concepts of cell growth and differentiation. Each scientist was asked to present a topic of their research related to cell growth and regeneration and to participate in a round table conference elaborating on current knowledge and sharing their experiences. By furthering this promising area of endeavor, a means of understanding ontogeny of cell development and of providing insights into tumor biology would prevail. Of prime importance was the anticipation that new informa...
Mechanisms of Lymphocyte Activation and Immune Regulation IV
In recent years rapid progress has been made in the areas of T cell and B cell biology, cell-cell and cell-matrix/stroma interactions. The use of isolated subunits of the T cell receptor invariant chains has been instrumental in defining their role in signal transduction and tyrosine phosphorylation. A role of src family phosphotyrosine kinases in T cell activation has been demonstrated and several phosphotyrosine kinase substrates have been identified and their functions characterized. Homologous recombinant techniques have led to the development of murine strains that lack CD4 or CD8 expression. These models are likely to be instrumental in studying the role of T cell subsets in autoimmune...
Prostate Cancer and Bone Metastasis
The biology of solid tumor metastasis has been the subject of significant scientific and clinical interest for years and while experimental evidence reveals that metastasis is not solely a random event, very little is known about the biology of metastasis originating from prostate cancer. This is in spite of the fact that the majority of prostate cancer patients die with metastatic lesions to the bone. Progress in understanding this most important aspect of prostate cancer has been hampered by the lack of suitable animal models and an inability to accurately quantify bone metastases and their responses to therapy. Over the past decade, scientists in Japan and the United States have steadily ...
Exercise, Calories, Fat and Cancer
The American Institute for Cancer Research (AICR) sponsored its second annual conference on nutrition and cancer. The theme was "Exercise, Calories, Fat, and Cancer" and the conference was held September 4-5, 1991 at the Ritz Carlton Hotel in Pentagon City, Virginia. This proceedings volume contains chapters from the platform presentations and abstracts from each poster presentation. Relationships among physical activity, calorie consumption, energy expenditure, dietary fat, and cancer are described in the context of epidemiologic, animal, and in vitro studies. Dietary recommendations to lower cancer risk are based on expanding evidence relating nutrition and cancer. Identification of the pr...
Chemical Induction of Cancer
In the approach to the analysis of disease, including, of course, cancer, two major thrusts may be distinguished. These may be referred to, in shorthand, as agents and processes: the causative agents (chemical, microbial, physical, environmental, and psychosocial) and the organismic processes, initiated and furthered by the agents, culminating in observable pathology (at the macromolecular, cytological, histological, organ function, locomotor, and behavioral levels). The past 25 years, since the appearance of the first volume of the predecessor series (1) authored by the Editors of this present volume, have seen an impressive number of studies on chemicals (and other agents) as etiologic fac...
Cancer and the Search for Selective Biochemical Inhibitors
The world of medicine has become splintered into two factions, that of orthodoxy and its counterpart, alternative or complementary medicine. A problem with alternative medicine is, of course, that of anecdote and hearsay. The solution: the disclosure, in an unassailable fashion, of the underlying biochemical principles for alternative cancer therap
Inorganic and Nutritional Aspects of Cancer
For many decades, cancer research concentrated heavily on "or ganic" aspects of the disease and ignored the role of trace elements and minerals in carcinogenesis and tumor growth. However, in recent years, spectacular progress has been made in "inorganic" cancer research: numerous inorganic substances were shown to possess car cinogenic properties. Quite unexpectedly, certain coordination compounds of platinum were found to have powerful antineoplastic properties, and a number of essential trace elements were demon strated to have profound effects on the genesis and growth of spontaneous, induced, or transplanted tumors. It therefore appeared desirable to call upon leading authorities in the...
