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Alzheimer: 100 Years and Beyond
Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4, 1906 in Tübingen. The celebratory event "Alzheimer 100 Years and Beyond" was organized through the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen. This volume, a collection of articles by the invited speakers and of a few other prominent researchers, is published as a record of those events.
Charney & Nestler's Neurobiology of Mental Illness
In the years following publication of the DSM-5(R), the field of psychiatry has seen vigorous debate between the DSM's more traditional, diagnosis-oriented approach and the NIMH's more biological, dimension-based RDoC (research domain criteria) approach. Charney & Nestler's Neurobiology of Mental Illness is an authoritative foundation for translating information from the laboratory to clinical treatment, and its fifth edition extends beyond this reference function to acknowledge and examine the controversies, different camps, and thoughts on the future of psychiatric diagnosis. In this wider context, this book provides information from numerous levels of analysis, including molecular biology...
The Aging Clock
The pineal is regarded as an ontogenic and evolutionary point of departure for research on the causes of senescence, suppported by in vivo experimental evidence, such as pineal cross-transplantation. Among the findings reported here, that reinforce the concept of the central clock, is the unique ability of melatonin to keep dangerous hydroxyl radicals under control. In addition, studies on the effect of caloric restriction and nutritional factors are building blocks in the understanding of how and why we age and develop cancer, together with other studies such as: the role of ubiquitous zinc and of extra-pineal melatonin; the disruption of biological rhythms; ultra-structure in brain diseases and dementia; the transacting factors as key regulatory proteins that mediate families of stress response genes; the aging antigen; the mother steroid DHEA during aging; the role of protein kinase C; the loss of D2 dopamine receptors during aging; brain amyloid formation; the role of cell cycles and cyclic AMP; the pineal peptides; and the decay of central neuro-endocrine-immune functions during aging.
Proteopathic Seeds and Neurodegenerative Diseases
The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disord...
Das Schweizer Buch
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Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research
Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Meth...
Greek and Roman Sculpture in Gold and Silver
This is a handy introduction to the technique and themes of Classical metal sculptures, illustrated with over 100 catalogued objects; many from the Museum of Fine Arts in Boston but other excellent examples from all over the world.
