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Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease
The advent of next-generation sequencing technologies has resulted in a remarkable increase our understanding of human and animal neurological disorders through the identification of disease causing or protective sequence variants. However, in many cases, robust disease models are required to understand how changes at the DNA, RNA or protein level affect neuronal and synaptic function, or key signalling pathways. In turn, these models may enable understanding of key disease processes and the identification of new targets for the medicines of the future. This e-book contains original research papers and reviews that highlight either the impact of next-generation sequencing in the understanding of neurological disorders, or utilise molecular, cellular, and whole-organism models to validate disease-causing or protective sequence variants.
Cellular Electron Microscopy
Recent advances in the imaging technique electron microscopy (EM) have improved the method, making it more reliable and rewarding, particularly in its description of three-dimensional detail. Cellular Electron Microscopy will help biologists from many disciplines understand modern EM and the value it might bring to their own work. The book’s five sections deal with all major issues in EM of cells: specimen preparation, imaging in 3-D, imaging and understanding frozen-hydrated samples, labeling macromolecules, and analyzing EM data. Each chapter was written by scientists who are among the best in their field, and some chapters provide multiple points of view on the issues they discuss. Each...
Protein-protein Interactions and Networks
The biological interactions of living organisms, and protein-protein interactions in particular, are astonishingly diverse. This comprehensive book provides a broad, thorough and multidisciplinary coverage of its field. It integrates different approaches from bioinformatics, biochemistry, computational analysis and systems biology to offer the reader a comprehensive global view of the diverse data on protein-protein interactions and protein interaction networks.
The Man Who Invented the Chromosome
Born by mistake, or connivance, to struggling parents in a small Lancashire cotton town in 1903, an uninspired Darlington inadvertently escaped the obscurity of farming life and rose instead, against all odds, to become within a few short years the world's greatest expert on chromosomes, and one of the most penetrating biological thinkers of the twentieth century. Harman follows Darlington's path from bleak prospects to world fame, showing how, within the most miniscule of worlds, he sought answers to the biggest questions--how species originate, how variation occurs, how Nature, both blind and foreboding, random and insightful, makes her way from deep past to unknown future. But Darlington ...
Practical Bioinformatics
This book presents applications of bioinformatics tools that experimental research scientists use in "daily practice." Its interdisciplinary approach combines computational and experimental methods to solve scientific problems. The book begins with reviews of computational methods for protein sequence-structure-function analysis, followed by methods that use experimental data obtained in the laboratory to improve functional predictions.
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Genomics with Care
In Genomics with Care Mike Fortun presents an experimental ethnography of contemporary genomics, analyzing science as a complex amalgam of cognition and affect, formal logics and tacit knowledge, statistics, and ethics. Fortun examines genomics in terms of care—a dense composite of affective and cognitive forces that drive scientists and the relations they form with their objects of research, data, knowledge, and community. Reading genomics with care shows how each resists definition yet is so entangled as to become indistinguishable. Fortun analyzes four patterns of genomic care—curation, scrupulousness, solicitude, and friendship—seen in the conceptual, technological, social, and methodological changes that transpired as the genetics of the 1980s became the genomics of the 1990s, and then the “post-genomics” of the 2000s. By tracing the dense patterns made where care binds to science, Fortun shows how these patterns mark where scientists are driven to encounter structural double binds that are impossible to resolve, and yet are where scientific change and creativity occur.
