Welcome to our book review site go-pdf.online!

You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.

Sign up

Molecular Biology of RNA Tumor Viruses
  • Language: en
  • Pages: 540

Molecular Biology of RNA Tumor Viruses

  • Type: Book
  • -
  • Published: 2012-12-02
  • -
  • Publisher: Elsevier

Molecular Biology of RNA Tumor Viruses deals with the molecular biology and biologic significance of RNA tumor viruses. Methods and procedures with broad application to diverse areas of molecular biology, including cell culture procedures, competition radioimmunoassays, molecular hybridization, oligonucleotide mapping, heteroduplex mapping, and restriction endonuclease techniques, are considered. This book is organized into 12 chapters and begins with a historical overview of tumor virology beginning with the early studies of Peyton Rous and leading up to the significant surge of activity during the later decade. The biology of endogenous retroviruses, their transmission both within and betw...

Morphogens in the Wiring of the Nervous System
  • Language: en
  • Pages: 232

Morphogens in the Wiring of the Nervous System

Neuronal function relies on the establishment of proper connections between neurons and their target cells during development. This basic statement involves several cellular processes, such as neuronal differentiation, the polarized outgrowth of axons and dendrites from differentiated neurons, and the pathfinding of axons towards target cells. The subsequent recognition of complementary synaptic partners finally triggers the formation, maturation, and maintenance of functional synapses. Morphogens are secreted signaling molecules that regulate tissue patterning and cell identity during early embryonic development. Remarkably, growing evidence over the last years arising from different invertebrate and vertebrate model organisms has shown that, after cell fate has been established, morphogens also control the precise wiring of the nervous system.

The Chromosomal Imbalance Theory of Cancer
  • Language: en
  • Pages: 354

The Chromosomal Imbalance Theory of Cancer

  • Type: Book
  • -
  • Published: 2016-04-19
  • -
  • Publisher: CRC Press

Exploring the chromosomal imbalance (aneuploidy) theory of cancer, this volume describes how cancer is initiated and why progression takes years to decades. It clarifies why cancer cells often become drug resistant, provides objective, quantitative measures for detecting cancer and monitoring its progression, and suggests non-toxic strategies of ca

The Limits of Sisterhood
  • Language: en
  • Pages: 400

The Limits of Sisterhood

The authors alternate their own analyses of the lives of Catharine Esther Beecher, Harrier Beecher Stowe, and Isabella Beecher Hooker with excerpts from the sisters' private and public papers which illustrate key themes within the nineteenth century debate about the woman's sphere.

A Dictionary of Biomedicine
  • Language: en
  • Pages: 618

A Dictionary of Biomedicine

Contains entries on all areas of biomedicine, the study of molecular bioscience relating to disease. Includes terms from the related areas of anatomy, genetics, molecular bioscience, pathology, pharmacology, and clinical medicine.

Regulation and Genetics
  • Language: en
  • Pages: 625

Regulation and Genetics

The time seems ripe for a critical compendum of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and numbering, has probably reached that stage at which relatively few new-truly new-viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, biochemical cytology, and high-resolution microscopy and spectroscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of about 22 volumes, represents a commi...

Retroviruses
  • Language: en
  • Pages: 856

Retroviruses

  • Type: Book
  • -
  • Published: 1997
  • -
  • Publisher: CSHL Press

For over 25 years the study of retroviruses has underpinned much of what is known about information transfer in cells and the genetic and biochemical mechanisms that underlie cell growth and cancer induction. Emergent diseases such as AIDS and adult T-cell lymphoma have widened even further the community of investigators directly concerned with retroviruses, a development that has highlighted the need for an integrated understanding of their biology and their unique association with host genomes. This remarkable volume satisfies that need. Written by a group of the field's most distinguished investigators, rigorously edited to provide a seamless narrative, and elegantly designed for clarity and readability, this book is an instant classic that demands attention from scientists and physicians studying retroviruses and the disorders in which they play a role.

In vivo Models of HIV Disease and Control
  • Language: en
  • Pages: 445

In vivo Models of HIV Disease and Control

An AIDS vaccine is still elusive and HIV treatment continues to develop multidrug resistance at alarming rates. Because of the similarities between HIV and immune deficiency infections in a variety of animals, it is only natural that scientists use these animals as models to study pathogenesis, treatment, vaccine development and many other aspects of HIV. Part of the series Infectious Agents and Pathogenesis, this volume reviews the immune deficiency virus in a variety of hosts. Pathogenesis, vaccine and drug development, epidemiology, and the natural history of the monkey, mouse, cat, cow, horse, and other animal viruses are detailed and compared to HIV. Also included are chapters on the history and future of animal models, as well as a chapter on ethical and safety considerations in using animal models for AIDS studies.

Annual Report
  • Language: en
  • Pages: 636

Annual Report

  • Type: Book
  • -
  • Published: 1987
  • -
  • Publisher: Unknown

None

RAS Drug Discovery
  • Language: en
  • Pages: 839

RAS Drug Discovery

  • Type: Book
  • -
  • Published: 2024-10-08
  • -
  • Publisher: Elsevier

KRAS Drug Discovery: Past, Present and Future is a comprehensive overview of the state-of-the-art medicinal chemistry approaches towards targeting the formerly undruggable oncogene, KRAS. It includes Seminal medicinal chemistry case histories of KRASG12C inhibitors such as Sotorosib, the first approved KRASG12C inhibitor for NSCLC, alongside the latest advances towards identification of in vivo tools and development candidates targeting KRAS G12D, KRAS G13C and other mutations. The book also provides the reader with a comprehensive overview of the in vitro assay systems, in vivo pharmacology xenograft models and chemical biology tools available to characterize small molecule inhibitors of KRAS. - Highlights key structure-based drug design (SBDD) innovations to generate potency and selectivity vs. KRAS - Analyzes medicinal chemistry case histories for seminal contributions to the KRAS field - Provides an overview of in vitro and in vivo methods for drugging KRAS