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Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications
In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour suppression as all of these outcomes result in restriction of the growth and/or elimination of damaged and pre-malignant cells. Thus, a large number of anti-cancer agents target specific components of stress response signalling pathways with the aim of causing tumour regression by stimulating cell death. However, the efficacy of these agents is often impaired due to mutations in genes that are involved in these stress-responsive signalling pathways and instead the oncogenic ...
Protein Kinases
Proteins are the work horses of the cell. As regulators of protein function, protein kinases are involved in the control of cellular functions via intricate signalling pathways, allowing for fine tuning of physiological functions. This book is a collaborative effort, with contribution from experts in their respective fields, reflecting the spirit of collaboration - across disciplines and borders - that exists in modern science. Here, we review the existing literature and, on occasions, provide novel data on the function of protein kinases in various systems. We also discuss the implications of these findings in the context of disease, treatment, and drug development.
Research Methods in Theatre and Performance
How have theatre and performance research methods and methodologies engaged the expanding diversity of performing arts practices? How can students best combine performance/theatre research approaches in their projects? This book's 29 contributors provide
Uncanny Magazine Issue 59
The July/August 2024 issue of Hugo Award-winning Uncanny Magazine. Featuring new fiction by Sarah Pinsker, Greg van Eekhout, Sunwoo Jeong, John Chu, AnaMaria Curtis, Eleanna Castroianni, and Megan Chee. Essays by John Scalzi, Marissa Lingen, Del Sandeen, and Natania Barron, poetry by Terese Mason Pierre, Natasha King, Roshani Chokshi, and Abdulkareem Abdulkareem, interviews with Greg van Eekhout and AnaMaria Curtis by Caroline M. Yoachim, a cover by Broci, and an editorial by Lynne M. Thomas and Michael Damian Thomas. Uncanny Magazine is a bimonthly science fiction and fantasy magazine first published in November 2014. Edited by 2016, 2017, 2018, 2019, 2020, 2022, 2023 Hugo award winners for best semiprozine, and 2018 Hugo award winners for Best Editor, Short Form, Lynne M. Thomas and Michael Damian Thomas, and Monte Lin, each issue of Uncanny includes new stories, poetry, articles, and interviews.
Shipping in Inuit Nunangat
Shipping in Inuit Nunangat is a timely multidisciplinary volume offering novel insights into key maritime governance issues in Canadian Arctic waters that are Inuit homeland (Inuit Nunangat) in the contemporary context of climate change, growing accessibility of Arctic waters to shipping, the need to protect a highly sensitive environment, and the United Nations Declaration on the Rights of Indigenous Peoples. The volume includes policy, legal and institutional findings and recommendations intended to inform scholars and policymakers on managing the interface between shipping, the marine environment, and Indigenous rights in Arctic waters.
Sea Change
As climate change, resource overexploitation, and pollution leave ever more visible marks, ocean ecosystems, economies, and people are all affected. With coasts on the Atlantic, Pacific, and Arctic, Canada faces a formidable challenge in building resilient, sustainable oceans and supporting the communities that rely on them. Sea Change reports on the OceanCanada Partnership, a multidisciplinary project to take stock of what we know about Canada’s oceans, construct possible scenarios for coastal regions, and create a national dialogue and vision. Three themes emerge from this impressive synthesis of social, cultural, economic, and environmental research: ocean change, access to ocean resources, and ocean governance. Indigenous and non-Indigenous scholars and practitioners focus on finding solutions to rapid environmental and social transformation, outlining the implications for legislation and offering policy recommendations. Increasingly, civil society will have to advocate for oceans, and Sea Change will empower the voices of those who take up that task.
Transboundary Environmental Governance
Effective protection of the marine and terrestrial environment increasingly requires cooperation between neighbouring States, international organizations, government entities and communities within States. This book analyses key aspects of transboundary environmental law and policy and their implementation in Asia, Australasia and Australian offshore territories, and surrounding areas beyond national jurisdiction including Antarctica. It discusses the potential for implementing key transboundary environmental mechanisms such as the 1991 Convention on Environmental Impact Assessment in a Transboundary Context (Espoo Convention) and its 1997 Protocol on Strategic Environmental Assessment (Kiev Protocol) in Australia and Asia drawing on experience from other regions and the potential application of these agreements to all UN member states. The book makes an innovative contribution to research in the area of transboundary environmental governance particularly as it applies to Asia, Australasia and international areas, supplementing similar research which has predominantly focused on Europe and North America.
Using Postmodern and Poststructural Approaches in Applied Research
Using Postmodern and Poststructural Approaches in Applied Research introduces the complex theoretical approaches of postmodern and poststructural thought in ways that are accessible and understandable. The book begins by grounding our discussion with the foundational work of scholars who first wrote about postmodern and poststructural approaches. We then follow with examples of how scholars continue to use these approaches and theories today and apply them in different practice areas. Examples are provided from the author’s own research, teaching, and mentorship along with activities for the reader, to support them with their own research and application of postmodern and poststructural thought. Interviews and reflections are shared from students and researchers who have used postmodern and poststructural approaches in their own work. This book is for students and researchers who want to use postmodern and poststructural approaches to make a difference in practice areas where they work or have connections. It intends to inspire, excite, and support students, academics, researchers, and practitioners to use postmodern and poststructural concepts in their everyday practices.
The Development of Generativity across Adulthood
This volume brings together experts in generativity and related fields to provide a compelling overview of contemporary research and theory on this topic. Generativity refers to a concern for - or acting towards - the benefit of future generations as a legacy of the self; it has implications for outcomes at the individual, relational and social, and broader societal levels. Understanding the role and expressions of generativity at various stages of our lives is important to our sense of well-being and purpose, and it impacts our parenting, caregiving, and social relationships, as well as having implications for our activities and experiences in the workforce, and in voluntary activities in o...
