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Cytotoxicity
Compensating for cytotoxicity in the multicellular organism by a certain level of cellular proliferation is the primary aim of homeostasis. In addition, the loss of cellular proliferation control (tumorigenesis) is at least as important as cytotoxicity, however, it is a contrasting trauma. With the disruption of the delicate balance between cytotoxicity and proliferation, confrontation with cancer can inevitably occur. This book presents important information pertaining to the molecular control of the mechanisms of cytotoxicity and cellular proliferation as they relate to cancer. It is designed for students and researchers studying cytotoxicity and its control.
Tulip of İstanbul
None
Protein Stability
The topics covered by this volume include: protein destabilization at low temperatures; engineering the stability and function of Gene V Protein; free energy balance in protein folding; modelling protein stability as a heteropolymer collapse; stability of alpha helices; protein stability with T4 Lysozyme.
Alecsandri.Poezii
None
Tales Alive in Turkey
Sixty-seven folktales and anecdotes recorded and translated for those seeking an introduction to the Turkish tradition of oral literature.
Essays in Ottoman and Turkish History, 1774-1923
The effect of Western influence on the later Ottoman Empire and on the development of the modern Turkish nation-state links these twelve essays by a prominent American scholar. Roderic Davison draws from his extensive knowledge of Western diplomatic history and Turkish history to describe a period in which the actions of the Great Powers, incipient and rising nationalisms, and Westernizing reforms shaped the destiny of the Ottoman Empire and the creation of the new Turkish Republic. Eleven of the essays were previously published in widely scattered journals and multi-authored volumes. The first of these provides a general survey of Turkish and Ottoman history, from early Turkish times to the...
Two Faces of Evil: Cancer and Neurodegeneration
Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes
A Provincial History of the Ottoman Empire
Provincializing the history of the Ottoman Empire, this book provides a critical approach to the projects of ‘modernity’ that took place in the Eastern Mediterranean over the past two centuries. Leaving their mark on this period are; the turmoil of insurgency in Greece and Egypt, a growing intervention of European Powers in Eastern Mediterranean politics, and the unfolding of large reform projects within the administration of the Ottoman Empire. Whilst these developments have prompted enduring debates over Middle Eastern paths of transformation, the case of Cyprus has remained isolated from these discussions, something this book seeks to address. One of the first research monographs to a...
