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Intracranial Gliomas Part II - Adjuvant Therapy
Treatment of patients with intracranial gliomas, especially high-grade neoplasms, usually requires postoperative adjuvant therapy. Significant progress in the understanding of tumor biology, technological advances in irradiation delivery, and development of novel antitumor drugs have led to an expansion of the therapeutic arsenal in neuro-oncology. This publication provides a unique review of the various options for adjuvant therapy. Special emphasis is on current evidence-based treatment standards and guidelines, and on perspectives of further improvement in long-term outcomes. Chapters review the histopathological and molecular features of gliomas and describe basic principles and clinical results of fractionated radiotherapy, stereotactic radiosurgery, brachytherapy, use of radiosensitizers, systemic chemotherapy and antiangiogenic therapy. Particular attention is paid to treatment of pediatric patients and to physical and psychological rehabilitation and supportive care at the end of life. This book and its accompanying volumes are mainly directed at neuro-oncologists, radiation oncologists, and other clinicians treating patients with brain tumors.
Intracranial Gliomas Part III - Innovative Treatment Modalities
At present most intracranial gliomas are considered incurable with current treatment strategies, and the search for new modalities that may effectively control tumor growth continues. The chapters in this volume describe basic principles and therapeutic possibilities of several innovative techniques, including photodynamic therapy, laser-induced interstitial thermotherapy, stereotactic cryodestruction, high-intensity focused ultrasound ablation, boron neutron capture therapy, proton and carbon ion irradiation, targeted therapy, immunotherapy, gene therapy, local chemotherapy, and alternating electric fields therapy. Potential applications of extracellular vesicles and nanotechnology for management of gliomas are highlighted as well. Many of these methods have already demonstrated antitumor efficacy in clinical testing, whereas others are still under development. The materials presented in this book are mainly directed at clinicians treating patients with brain tumors, as well as clinical and basic researchers working in the field of neuro-oncology.
Intracranial Gliomas Part I - Surgery
Aggressive surgical removal is generally considered the main initial management option for most intracranial gliomas. It often results in resolution or alleviation of neurological symptoms and signs, normalizes intracranial pressure, facilitates characterization of the neoplasm, creates optimal conditions for adjuvant therapy and neurorehabilitation, and leads to prolongation of progression-free and overall survival of patients. Leading experts in neurosurgical oncology have contributed to this volume, highlighting modern principles of surgery for both newly-diagnosed and recurrent intracranial gliomas in adult as well as pediatric patients. The first of a three-volume set, it details epidemiological aspects, defines the importance of preoperative imaging, and describes current perioperative adjuvant needs. In addition, contemporary methods of intraoperative neurophysiological monitoring, the value of brain mapping for functional preservation, tips to prevent complications, and postoperative results are presented and discussed. This book and its accompanying volumes are mainly directed at neurosurgeons, neuro-oncologists and other clinicians treating patients with brain tumors.
United Nations—Advances in Research and Application: 2012 Edition
United Nations—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about United Nations in a concise format. The editors have built United Nations—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about United Nations in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of United Nations—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Gamma Knife Neurosurgery in the Management of Intracranial Disorders
The articles in this volume cover the various options of the optimal management of brain tumors, vascular lesions, and functional disorders. They provide a good balance between microneurosurgery and radiosurgery, presenting also alternative surgical and radiosurgical treatment options with discussions on their advantages and disadvantages. The presentation of multiple treatment methods will help to provide better service to patients. Some papers, specifically highlighting alternative treatment options, are accompanied by editorials prepared by recognized experts in the field. Additional emphasis is put on importance of the advanced neuroimaging techniques for radiosurgical treatment planning and subsequent follow-up.
Leksell Radiosurgery
Since its introduction 52 years ago, Leksell radiosurgery has become a widely applied technique for the management of a diverse group of vascular, neoplastic, and functional disorders. This publication presents an update on state-of-the-art radiosurgery technology, including outcomes, by the pioneers in the field. Experts have contributed chapters on various topics. They provide a history of the development of Leksell Gamma Knife and its evolution from frame-based to the inclusion of mask-based radiosurgery in the latest Gamma Knife model. For beginners, there is valuable information related to imaging, quality assurance, patient care, anesthesia, and regulatory requirements. Advance users will appreciate the summary of the long-term outcome of important indications. Additional chapters on cavernous malformation, orbital, uveal, and ocular disorders clarify the role of radiosurgery. This book is a concise overview for physicians interested in radiosurgery. It will be of great value to neurosurgeons, radiation oncologists, and medical physicists concerned with learning about the indications of radiosurgery.
Nuclear Magnetic Resonance
As a spectroscopic method, nuclear magnetic resonance (NMR) has seen spectacular growth, both as a technique and in its applications. Today's applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive coverage of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules, which is covered in two reports: NMR of Proteins and Nucleic Acids and NMR of Carbohydrates, Lipids and Membrane...
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