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Chronic Myeloid Leukemia
Chronic Myeloid Leukemia (CML) remains a key model for the improved understanding of the pathophysiology of a malignancy at a molecular level and has been used by researchers to develop a variety of therapies and therapeutic assessment methods. This concise, readable guide assembles and synthesizes the latest developments and trends in the treatmen
Hematology Board Review
Note to Readers: Publisher does not guarantee quality or access to any included digital components if book is purchased through a third-party seller. Now with a free mobile & web app with print purchase Hematology Board Review: Blueprint Study Guide and Q&A is a concise, outline-based study guide covering all topics that appear on the Hematology Certification Exam. The book includes all topics listed in the American Board of Internal Medicine (ABIM) blueprint as essential material for the exam and highlights topic areas that are often found on the test. For hematology and oncology fellows as well as practicing clinicians needing a refresher before taking MOC, this handy study guide which com...
Names of Foreigners Who Took the Oath of Allegiance to the Province and State of Pennsylvania, 1727-1775. with the Foreign Arrivals, 1786-1808
In 1727, the Pennsylvania Provincial Council passed a law requiring all "foreign" immigrants (i.e. those of non-British origin) to swear an oath of allegiance to the Crown. Lists of these immigrants were originally assembled for publication in the Pennsylvania Archives (Ser. 2, Vol. XVII), and they are reprinted here without change. This work, then, is an exhaustive list of "foreigners"-mostly Germans-who immigrated into the Province and, later, the State of Pennsylvania between the years 1727 and 1775 and again during the years 1786-1808. More to the point, it is a collection of ships' passenger lists, in many cases the lists being transcribed in entirety, with Captains' lists of passengers running up to the relatively late year of 1808. Along with the full name of the immigrant, including the names of all males over the age of sixteen, since that was the age they were obliged to take the oath, such information is given as name of ship, date of arrival, port of origin, and, in some instances, ages, names of wives, and names of children. An exhaustive index of surnames, running to more than 100 pages, contains about 35,000 references.
Notes and Queries
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Novel Developments in Stem Cell Mobilization
Recently the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development effective antagonists. One antagonist, plerixafor, is clinically approved now for stem cell mobilization of lymphoma and myeloma patients. This allows patients to receive potentially life-saving treatment which could not have been administered otherwise. Through early clinical studies it was recognized that CXCR4 antagonists also mobilize malignant hematopoetic cells, i.e. leukemia cells. In preclinical studies a sensitization of mobilized leukemic cells to standard cytotoxic chemotherapy could be shown. Clinical studies are under way. CXCR4 antagonists are an exciting new class of compounds which are also employed for the mobilization of angiogenic cells or for the treatment of solid tumors. In this book a concise review of the current status of knowledge and future developments will be presented.
A collection of upwards of thirty thousand names of German, Swiss, Dutch, French and other immigrants in Pennsylvania from 1727 to 1776
A collection of upwards of thirty thousand names of German, Swiss, Dutch, French and other immigrants in Pennsylvania from 1727 to 1776: With a Statement of the Names of Ships, Whence They Sailed, and the Date of Their Arrival at Philadelphia.
