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Green Techniques for Organic Synthesis and Medicinal Chemistry
Green chemistry is a new way of looking at organic synthesis and the design of drug molecules, offering important environmental and economic advantages over traditional synthetic processes. Pharmaceutical companies are increasingly turning to the principles of green chemistry in an effort to reduce waste, reduce costs and develop environmentally benign processes. Green Techniques for Organic Synthesis and Medicinal Chemistry presents an overview of the established and emerging techniques in green organic chemistry, highlighting their applications in medicinal chemistry. The book is divided into four parts: Introduction: Introduces the reader to the toxicology of organic chemicals,their envir...
Neglected Tropical Diseases
A drug discovery reference to the crippling tropical diseases that affect more than 1 billion people. Neglected Tropical Diseases is the first book of its kind to offer a guide that follows the World Health Organization?s list of neglected tropical diseases. The authors?all are experts on the topic?address the development of effective treatments for 12 crippling infectious diseases that affect almost 20% of the world?s popluation. The book includes information on the common approaches and the most important factors that lead to the development of new drugs for treating tropical diseases. Individual chapters review 12 neglected tropical diseases that are grouped by infectious agent, from viru...
Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set
Burger’s Medicinal Chemistry, Drug Discovery and Development Explore the freshly updated flagship reference for medicinal chemists and pharmaceutical professionals The newly revised eighth edition of the eight-volume Burger’s Medicinal Chemistry, Drug Discovery and Development is the latest installment in this celebrated series covering the entirety of the drug development and discovery process. With the addition of expert editors in each subject area, this eight-volume set adds 35 chapters to the extensive existing chapters. New additions include analyses of opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic co...
New advances in the biology and pathogenesis of free-living amoebae
Free-living amoebae (FLA) are fascinating unicellular eukaryotes, living freely in soil and freshwater habitats and feeding mainly on bacteria. Under stressful conditions, they can transform from a motile, metabolically active, and replicative trophozoite to a “dormant” and resistant cyst. Some FLA can be pathogenic to humans such as Acanthamoeba, Balamuthia, Naegleria, and Sappinia causing rare but fatal infection in humans. FLA are also known to be carriers of pathogenic microorganisms, but few information is currently available on the natural bacteria of FLA and how various bacteria avoid phagocytosis/predation by these specific types of amoebae. There is an imperious need to draw more attention to this group of microorganisms and for this we seek submissions that address advancements in the biology and pathogenesis of FLAs.
Plant Polyphenols 2
This volume summarizes current research on the influence of plant polyphenols on human health, promoting collaboration between chemists and biologists to improve our understanding of their biological significance, and expanding the possibilities for their use.
Chemtracts
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Phosphodiesterases and Their Inhibitors
Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug development options for all major human PDE families are discussed and cover diverse therapeutic fields, such as neurological/psychiatric, cardiovascular/metabolic, pain, and allergy/respiratory diseases. Finally, emerging chemotherapeutic applications of PDE inhibitors against malaria and other tropical diseases are discussed.
The Politics of Disease Control
A history of epidemic illness and political change, The Politics of Disease Control focuses on epidemics of sleeping sickness (human African trypanosomiasis) around Lake Victoria and Lake Tanganyika in the early twentieth century as well as the colonial public health programs designed to control them. Mari K. Webel prioritizes local histories of populations in the Great Lakes region to put the successes and failures of a widely used colonial public health intervention—the sleeping sickness camp—into dialogue with African strategies to mitigate illness and death in the past. Webel draws case studies from colonial Burundi, Tanzania, and Uganda to frame her arguments within a zone of vigoro...
Abstracts of Papers
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