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The Incarnality of Being
The Incarnality of Being addresses Martin Heidegger's tendency to neglect the problem of the body, an omission that is further reflected in the field of Heidegger scholarship. By addressing the corporeal dimension of human existence, author Frank Schalow uncovers Heidegger's concern for the materiality of the world. This allows for the ecological implications of Heidegger's thought to emerge, specifically, the kinship between humans and animals and the mutual interest each has for preserving the environment and the earth. By advancing the theme of the "incarnality of being," Schalow brings Heidegger's thinking to bear on various provocative questions concerning contemporary philosophy: sexuality, the intersection of human and animal life, the precarious future of the earth we inhabit, and the significance that reclaiming our embodiment has upon ethics and politics.
Selective Estrogen Receptor Modulators
Experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of co-activators and co-repressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentation reviews the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A tentative approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer.
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