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The molecular modeling perspective in drug design. (N. Calude Cohen). Molecular graphics and modeling: tools of the trade. (Roderick E. Hubbard). Molecular modeling of small molecules. (Tamara Gund). Computer assisted new lead design. (Akiko Itai, Miho Yamada Mizutani, Yoshihiko Nishibata, and Nubuo Tomioka). Experimental techniques and data banks. (John P. Priestle and C. Gregory Paris). Computer-assisted drug discovery. (Peter Gund, Gerald Maggiora, and James P. Snyder). Modeling drug-receptor interactions. (Konrad F. Koehler, Shashidhar N. Rao, and James P. Snyder). Glossary of terminology. (J. P. Tollenaere).
Progress in medicinal chemistry and in drug design depends on our ability to understand the interactions of drugs with their biological targets. Classical QSAR studies describe biological activity in terms of physicochemical properties of substituents in certain positions of the drug molecules. The purpose of this book is twofold: On the one hand, both the novice and the experienced user will be introduced to the theory and application of 3D QSAR analyses, and on the other, a comprehensive overview of the scope and limitations of these methods is given. The detailed discussion of the present state of the art should enable scientists to further develop and improve these powerful new tools. Th...
This is a comprehensive sourcebook on the world's most famous vampire, with more than 700 citations of domestic and international Dracula films, television programs, documentaries, adult features, animated works, and video games, as well as nearly a thousand comic books and stage adaptations. While they vary in length, significance, quality, genre, moral character, country, and format, each of the cited works adopts some form of Bram Stoker's original creation, and Dracula himself, or a recognizable vampiric semblance of Dracula, appears in each. The book includes contributions from Dacre Stoker, David J. Skal, Laura Helen Marks, Dodd Alley, Mitch Frye, Ian Holt, Robert Eighteen-Bisang, and J. Gordon Melton.
This volume is the proceedings of the International Conference on Inhibin, Activin: Recent Advances and Future Views held in Tokushima, Japan from November 9-10, 1996. The Internationally recognized faculty present the latest research in the exploration of inhibin, activin and follistatin mechanisms of action.
These two volumes present the proceedings of the International Conference on Technology and Instrumentation in Particle Physics 2017 (TIPP2017), which was held in Beijing, China from 22 to 26 May 2017. Gathering selected articles on the basis of their quality and originality, it highlights the latest developments and research trends in detectors and instrumentation for all branches of particle physics, particle astrophysics and closely related fields. This is the second volume, and focuses on the main themes Astrophysics and space instrumentation, Front-end electronics and fast data transmission, Trigger and data acquisition systems, Machine detectors, Interfaces and beam instrumentation, Ba...
An entertaining reference to popular Japanese TV shows, from the publisher of The Anime Encyclopedia.
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