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Cell signalling is the communication inside a cell or with its environment. It plays an important role in cellular growth, survival and apoptosis. For instance, the growth of a cell requires production of certain proteins. The genes that encode these proteins are located in DNA inside the nucleus while the initial signal for cellular growth may come from outside the cell. To induce the expression of these genes, the external signal must pass through specific pathways to reach these genes in DNA. The signalling pathway involves several proteins. If any one of them becomes abnormal or non-functional, the cellular process would be altered, which may cause disease. Therefore, knowing the detailed pathway is very important in understanding the pathogenesis of diseases.
Western scholars of ancient Chinese ceramics have long thought blue and white porcelain manufactured before the Ming (1368-1644 A.D.), dates to the Yuan (1279-1368 A.D.). Even in China today these porcelains are still termed “Yuan Blue and White.” Based upon first-hand surveys of sites in Inner Mongolia, Adam T. Kessler’s Song Blue and White Porcelain on the Silk Road demonstrates that blue and white was made during the Song (960-1279 A.D.) ended up in the hands of the Xi Xia (1038-1226 A.D.) and the Jin (1115-1234 A.D.). Blue and white found today in hoards was buried prior to Mongol invasions of China in the 1200s. Sites from the Philippines to Egypt have yielded Song blue and white. Also reviewed is the cobalt-bearing ore used by Song China to create blue and white.
Enlightenment in Dispute is the first comprehensive study of the revival of Chan Buddhism in seventeenth-century China. Focusing on the evolution of a series of controversies about Chan enlightenment, Jiang Wu describes the process by which Chan reemerged as the most prominent Buddhist establishment of the time. He investigates the development of Chan Buddhism in the seventeenth century, focusing on controversies involving issues such as correct practice and lines of lineage. In this way, he shows how the Chan revival reshaped Chinese Buddhism in late imperial China. Situating these controversies alongside major events of the fateful Ming-Qing transition, Wu shows how the rise and fall of Chan Buddhism was conditioned by social changes in the seventeenth century.
This prestigious volume presents the findings of an international group of academic and biotechnological researchers. Topics range from early detection programs focusing on genetic factors, novel probes for detecting B-amyloid in the living brain, and the use of telephonic screening and MRI's to the diversity of therapeutic areas such as antioxidants, estrogen agonists and various anti-B-amyloid and anti-tangle approaches. The volume is still an indispensable resource for the psychogeriatrician, psychiatrist, clinical investigator, and neurobiologist, and a must for medical libraries.
This four-volume set (CCIS 643, 644, 645, 646) constitutes the refereed proceedings of the 16th Asia Simulation Conference and the First Autumn Simulation Multi-Conference, AsiaSim / SCS AutumnSim 2016, held in Beijing, China, in October 2016. The 265 revised full papers presented were carefully reviewed and selected from 651 submissions. The papers in this first volume of the set are organized in topical sections on modeling and simulation theory and methodology; model engineering for system of systems; high performance computing and simulation; modeling and simulation for smart city.
Stephen Owen is James Bryant Conant Professor of Chinese at Harvard University. --Book Jacket.