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Enterprise Risk Management
ERM is considered a dynamic capability that is critical to companies’ success from strategic and performance perspectives and is increasingly implemented in response to growing pressure from external stakeholders to enact and add legitimacy to existing management control systems. However, implementing ERM is a challenging process where success is dependent on balancing technical and social factors. This book explores the challenges of implementing ERM from technical, cognitive, and social perspectives to enhance the organisation’s capacity to generate and integrate information and knowledge about risk and uncertainty. In existing publications, ERM implementation is mainly viewed from tec...
Navigating the Ecological Transition
The transition towards sustainability is now a major issue that has taken centre stage in public debate, policy circles, scientific forums, and business roundtables. Higher education institutions focusing on educating tomorrow’s managers and leaders and on business practices are doubly challenged by this development. On the one hand, they must be accountable to their internal stakeholders who strongly identify with the new “environmental awakening”. On the other hand, because of their status as research institutions, they must provide answers and propose solutions to face this challenge which is shaping up to be the most crucial issue that humanity has had to face in the modern era. In...
Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs
Cancer is a multifaceted disease and overwhelmingly increasing experimental evidence has helped us to develop a deeper understanding of the role of signal transduction cascades in cancer development and progression. Tissue microarrays and next generation sequencing technologies have assisted us to gather missing pieces of jigsaw puzzle and we now know that deregulation of spatio-temporally controlled signaling cascades play fundamental role in metastasis and resistance against wide ranging therapeutics. This book offers a balanced overview of the rapidly emerging cutting edge research in molecular oncology and good source of knowledge for established oncologists, basic and medical students and pharmaceutical industry associated R&D departments.
Working Capital Management: Concepts And Strategies
Working capital refers to the money that a company uses to finance its daily operations. Proper management of working capital is critical to financial health and operational success. Working capital management (WCM) aims to maximize operational efficiency by maintaining a delicate balance among growth, profitability, and liquidity. WCM is a continuous responsibility focusing on a firm's day-to-day operations involving short-term assets and liabilities. By efficiently managing a firm's cash, accounts receivable, inventories, and accounts payable, managers can help maintain smooth operations and improve a company's earnings and profitability. By contrast, poor WCM could lead to a lower credit ...
Current Applications for Overcoming Resistance to Targeted Therapies
Targeted therapies were initially developed to exploit the upregulation and dependence on key oncogenic pathways critical to cancer progression. Additionally, they also presented as a method to overcome chemoresistance by supplementing conventional therapeutic regimens with targeted therapies. However, the development of resistance to these combinatorial approaches has led to the reassessment of currently available therapeutic options to overcome resistance to targeted therapy. This book aims to provide an update on the advancements in the therapeutic arms race between cancer, clinicians and scientists alike to overcome resistance to targeted therapies. Subject experts provide a comprehensive overview of the challenges and solutions to resistance to several conventional targeted therapies in addition to providing a discussion on broad topics including targeting components of the tumor microenvironment, emerging therapeutic options, and novel areas to be explored concerning nanotechnology and the epigenome.
HIV-associated Hematological Malignancies
This book presents a general introduction to and review of HIV-associated hematological malignancies, with a special focus on practical management issues. Each of the relevant malignancies is addressed individually, with an overview of treatment approaches, assessment of evidence regarding their efficacy, and discussion of therapeutic controversies. In addition, careful consideration is paid to issues in molecular and clinical pathology, epidemiological aspects, symptomatology, diagnosis, and risk factors. Separate chapters are devoted to autologous and allogeneic stem cell transplantation and to chemotherapy and interactions with antiretroviral agents. Many of the chapters are written by ex...
