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Progress in Medicinal Chemistry
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Trauma surgery is a surgical specialty that utilizes both operative and non-operative management to treat traumatic injuries, typically in an acute setting. The trauma surgeon is responsible for initially resuscitating and stabilizing and later evaluating and managing the patient. Emergency surgery is surgery to treat trauma or acute illness after an emergency presentation. This book examines trauma and emergency surgery for abdominal, aortic, chest, brain, and burn injuries.
Dyslipidemia has a complex pathophysiology consisting of various genetic, lifestyle, and environmental factors. It has many adverse health impacts, notably in the development of chronic non-communicable diseases. Significant ethnic differences exist due to the prevalence and types of lipid disorders. While elevated serum total- and LDL-cholesterol are the main concern in Western populations, in other countries hypertriglyceridemia and low HDL-cholesterol are more prevalent. The latter types of lipid disorders are considered as components of the metabolic syndrome. The escalating trend of obesity, as well as changes in lifestyle and environmental factors will make dyslipidemia a global medical and public health threat, not only for adults but for the pediatric age group as well. Several experimental and clinical studies are still being conducted regarding the underlying mechanisms and treatment of dyslipidemia. The current book is providing a general overview of dyslipidemia from diverse aspects of pathophysiology, ethnic differences, prevention, health hazards, and treatment.
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Vitamin D insufficiency/deficiency is a worldwide, public health problem in both developed and developing countries. Rickets among infants has reemerged. Low levels of vitamin D are associated with increased risk and mortality from cancer. At the same time, the beneficial effects of vitamin D on a host of conditions have recently been discovered. Focusing on areas not extensively covered in other comparable books, Vitamin D: Oxidative Stress, Immunity, and Aging highlights the most recent research findings on the impact of this nutrient in oxidative stress, immunity, and aging. A state-of-the-art compilation of essential information, this book explores: Vitamin D and its genomic and nongenom...
Physical Activity Epidemiology, Second Edition, provides a comprehensive discussion of current population-level studies showing the influence of physical activity on disease. Updated with extensive new research collected in the eight years since the previous edition, the second edition adds the expertise of respected epidemiologist I-Min Lee. To assist readers in understanding the public health significance of physical activity, Dishman, Heath, and Lee present a detailed review of research findings and what those findings suggest regarding the relationship between physical activity and a variety of health risks. The second edition of this groundbreaking text has been exhaustively updated to ...
High pressure mineral physics is a field that has shaped our understanding of deep planetary interiors and revealed new material phenomena occurring at extreme conditions. Comprised of sixteen chapters written by well-established experts, this book covers recent advances in static and dynamic compression techniques and enhanced diagnostic capabilities, including synchrotron X-ray and neutron diffraction, spectroscopic measurements, in situ X-ray diffraction under dynamic loading, and multigrain crystallography at megabar pressures. Applications range from measuring equations of state, elasticity, and deformation of materials at high pressure, to high pressure synthesis, thermochemistry of high pressure phases, and new molecular compounds and superconductivity under extreme conditions. This book also introduces experimental geochemistry in the laser-heated diamond-anvil cell enabled by the focused ion beam technique for sample recovery and quantitative chemical analysis at submicron scale. Each chapter ends with an insightful perspective of future directions, making it an invaluable source for graduate students and researchers.